临床医学工程2024，Vol.31Issue(2)：211-212,2.DOI:10.3969/j.issn.1674-4659.2024.02.0211
阿托伐他汀联合美托洛尔治疗CHF的效果及其治疗机制分析
Analysis on the Effect of Atorvastatin Combined with Metoprolol in the Treatment of CHF and Its Therapeutic Mechanism
王广辉 1魏新果1
作者信息
- 1. 河南省镇平县中医院心内科,河南南阳 474250
- 折叠
摘要
Abstract
Objective To explore the effect of atorvastatin combined with metoprolol in the treatment of chronic heart failure(CHF)and its therapeutic mechanism.Methods A total of 80 patients with CHF were randomly divided into two groups,with 40 cases in each group.The control group was treated with atorvastatin calcium,and the observation group was treated with metoprolol succinate on the basis of the control group.The therapeutic effect,serum indicators and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 95.00%,higher than 70.00%in the control group(P<0.05).After treatment,the levels of NT-proBNP and CysC in the observation group were lower than those in the control group(P<0.05).No significant difference was found in the incidences of nausea&vomiting,insomnia,dizziness&headache,diarrhea and dry mouth between the two groups(all P>0.05).Conclusions Atorvastatin combined with metoprolol has good effect and high safety in the treatment of CHF,and its therapeutic mechanism may be related to the inhibition of the expressions of NT-proBNP and CysC.关键词
阿托伐他汀/美托洛尔/慢性心力衰竭/治疗机制Key words
Atorvastatin/Metoprolol/Chronic heart failure/Therapeutic mechanism分类
医药卫生引用本文复制引用
王广辉,魏新果..阿托伐他汀联合美托洛尔治疗CHF的效果及其治疗机制分析[J].临床医学工程,2024,31(2):211-212,2.
