医学新知2024，Vol.34Issue(2)：217-225,9.DOI:10.12173/j.issn.1004-5511.202312035
Toll样受体在钙化性主动脉瓣疾病中的研究进展
Research progress of Toll-like receptors in calcified aortic valve disease
摘要
Abstract
Calcified aortic valve disease(CAVD)was believed to be caused by aging-associated degenerative changes and passive calcium deposition.In recent years,it has been found that CAVD is an active pathological process,but the possible pathogenesis of CAVD has not been elucidated.During the development of CAVD,both innate and adaptive immune responses are activated,and increasing evidence suggests that inflammation plays a central role in the initiation and progression of the disease,in which the function of Toll-like receptors(TLRs)is particularly important.TLRs play a crucial role in controlling infection and maintaining tissue homeostasis by identifying host derived molecules released after pathogen and tissue damage,acting as a sentinel for the innate immune system.This article provides an overview of the current concepts regarding the relationship between TLRs signaling and inflammation and calcification remodeling in the pathogenesis of CAVD.The above regulatory mechanisms can provide new targets and strategies for the treatment of CAVD.关键词
钙化性主动脉瓣疾病/Toll样受体/炎症反应Key words
Calcified aortic valve disease/Toll-like receptor/The inflammatory response引用本文复制引用
任一鸣,张晋辉,王聪聪,王天堃,任学群,周建良..Toll样受体在钙化性主动脉瓣疾病中的研究进展[J].医学新知,2024,34(2):217-225,9.基金项目
国家自然科学基金面上项目(82270382) （82270382）
武汉市英才产业领军人才项目(WHYCCYLK2021002) （WHYCCYLK2021002）
