中国动物检疫2024，Vol.41Issue(2)：103-107,5.DOI:10.3969/j.issn.1005-944X.2024.02.018
山羊口蹄疫、小反刍兽疫疫苗不同免疫剂量同步分点注射免疫效果比较
Comparison on Immune Effects of Synchronous Multiple-point Injection with Goat FMD and PPR Vaccines at Different Doses
摘要
Abstract
In order to explore a method and dosage for synchronous vaccination for goat foot-and-mouth disease(FMD)and peste des petits ruminants(PPR)at grassroots level,64 goats were randomly selected and divided into 4 groups:one group with routine vaccination(control group)and three experimental groups with synchronous multiple-point vaccination(groups of 1.0,1.2 and 1.5 doses),respectively,to compare the immune effects of different methods for FMD and PPR vaccines.The results showed that no immunological stress reaction was found in the vaccinated goats after the above injections with the two vaccines;and no statistically significant difference was detected among the positive rates of immune antibodies against FMD-O/A virus and PPR virus in each group for 14,28,42,56,70,100 and 160 days after vaccination at different doses(P＞0.05).On the 14th day after vaccination,the positive rate of antibodies against FMD-O virus in goats in the group of 1.2 doses was higher than that in the groups of 1.0 and 1.5 doses;on the 100th day after vaccination,the positive rate of antibodies against FMD-O virus in goats in the group of 1.5 doses was higher than that in other two experimental groups;on the 14th day after vaccination,the positive rate of antibodies against FMD-A virus in goats in control group was 87.5%;and that of other groups all reached up to 100%and lasted till on the 100th day.The positive rate of antibodies against PPR virus reached 100%in each group on the 14th day after vaccination and remained till on the 160th day.In conclusion,synchronous multiple-point vaccination with goat FMD and PPR vaccines could be conducted at the experimental doses,specifically,the doses of 1.2 and 1.0 were optimal for the vaccines of FMD and PPR,respectively,and better immune effect should be monitored on the 14th day after vaccination.Grassroots animal health workers were thus provided with a reference to efficiently and conveniently implement vaccination of FMD and PPR vaccines in goats.关键词
口蹄疫/小反刍兽疫/免疫剂量/同步分点注射Key words
FMD/PPR/immune dose/synchronous multiple-point injection分类
农业科技引用本文复制引用
高丽艳,陈关雄,杨晓燕,台晓媛,喻永福,张俊雄,李继明,段纲,李本能,李学德..山羊口蹄疫、小反刍兽疫疫苗不同免疫剂量同步分点注射免疫效果比较[J].中国动物检疫,2024,41(2):103-107,5.基金项目
云南省创新与科技型企业培育计划项目(202104BI090017) （202104BI090017）
云南省重大科技专项计划项目(202302AA310020) （202302AA310020）
