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首页|期刊导航|药物分析学报(英文)|Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

Hang Yu Zhao Zhai Jingyue Wang Jiandong Jiang Yan Wang Hui Xu Xinyu Yang Zhengwei Zhang Jiachun Hu Jinyue Lu Jie Fu Mengmeng Bu Haojian Zhang

药物分析学报(英文)2023,Vol.13Issue(9):1024-1040,17.
药物分析学报(英文)2023,Vol.13Issue(9):1024-1040,17.DOI:10.1016/j.jpha.2023.06.012

Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase

Hang Yu 1Zhao Zhai 1Jingyue Wang 1Jiandong Jiang 1Yan Wang 1Hui Xu 1Xinyu Yang 1Zhengwei Zhang 1Jiachun Hu 1Jinyue Lu 1Jie Fu 1Mengmeng Bu 1Haojian Zhang1

作者信息

  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing,100050,China
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摘要

关键词

Specnuezhenide/Pharmacokinetics/Tumor/Gut microbiota/Fungi/Metabolism

Key words

Specnuezhenide/Pharmacokinetics/Tumor/Gut microbiota/Fungi/Metabolism

引用本文复制引用

Hang Yu,Zhao Zhai,Jingyue Wang,Jiandong Jiang,Yan Wang,Hui Xu,Xinyu Yang,Zhengwei Zhang,Jiachun Hu,Jinyue Lu,Jie Fu,Mengmeng Bu,Haojian Zhang..Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase[J].药物分析学报(英文),2023,13(9):1024-1040,17.

基金项目

This project was supported by the National Key R&D Program of China(Grant No.:2022YFA0806400),the CAMS Innovation Fund for Medical Sciences(Grant Nos.:2022-I2M-1-028,2022-I2M-2-002,and 2021-I2M-1-007),the National Natural Science Founda-tion of China(Grant Nos.:81973290 and 82173888),and Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study,China(Grant No.:Z141102004414062).We would like to thank Shimadzu(China)Co.,Ltd.for technological support. (Grant No.:2022YFA0806400)

药物分析学报(英文)

OACSCD

2095-1779

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