中国动物检疫2024，Vol.41Issue(2)：108-112,5.DOI:10.3969/j.issn.1005-944X.2024.02.019
猪流行性腹泻灭活疫苗佐剂筛选
Selection of Adjuvants for Inactivated Vaccines against Porcine Epidemic Diarrhea
摘要
Abstract
In order to investigate the effect of different adjuvants on inactivated vaccines against porcine epidemic diarrhea(PED),vaccines were prepared by three adjuvants,i.e.,oil-in-water adjuvant A(O/W),water-in-oil adjuvant B(W/O)and water-oil-water adjuvant C(W/O/W),to vaccinate piglets at the age of 3～5 days,respectively,followed by challenge test as well as comprehensive evaluation on the immunization effect of the adjuvants.The results showed that the antibody levels of the vaccinated pigs in A and B adjuvant groups were lower than those in C adjuvant group;it was detected that,after virus challenge,only all the piglets in C adjuvant group were negative;and no organ lesion was found in all vaccinated piglets under autopsy.In conclusion,inactivated vaccines prepared with water-oil-water adjuvants were obviously superior to those with water-in-oil or oil-in-water adjuvants,which was safer and could be prioritized to prepare inactivated vaccines against PED.The preparation and production of PED vaccines were technically supported by the study.关键词
猪流行性腹泻/灭活疫苗/佐剂/选择Key words
PED/inactivated vaccine/adjuvant/selection分类
农业科技引用本文复制引用
沈娜,杨文欢,吴艳,马飞,王峰,张磊,冯平,麻文静,苏红萍,陈瑞,肖普辉,武永杰,代德华,李准,赵光明..猪流行性腹泻灭活疫苗佐剂筛选[J].中国动物检疫,2024,41(2):108-112,5.基金项目
陕西省教育厅服务地方专项(19JC043) （19JC043）
榆林学院高层次人才科研启动基金项目(20GK12,20GK13) （20GK12,20GK13）
榆林市科技局产学研合作项目(2019-103-5) （2019-103-5）
