中国临床药理学杂志2024，Vol.40Issue(4)：607-610,4.DOI:10.13699/j.cnki.1001-6821.2024.04.027
新型冠状病毒感染疫情前后成人社区获得性肺炎病原谱变化及分析
Pathogen spectrum changes and analysis of adult community-acquired pneumonia before and after the epidemic of novel coronavirus infection
摘要
Abstract
Objective To investigate the distribution characteristics of pathogens in adult community-acquired pneumonia(CAP)patients who visited the fever clinic before and after the outbreak of the novel coronavirus infection,and to provide theoretical basis for the diagnosis,treatment,and prevention of CAP.Methods CAP patients who visited the fever clinic of Peking University Third Hospital from June 2017 to July 2022 were included in the study and divided into pre-outbreak and post-outbreak groups based on the time point(January 24,2020,when Beijing entered the first-level COVID-19 prevention and control).Respiratory samples were collected and pathogen nucleic acid detection was performed using real-time fluorescence quantitative polymerase chain reaction.The detection and distribution of pathogens were analyzed.Results A total of 415 CAP patients were included,divided into pre-outbreak group(312 cases)and post-outbreak group(103 cases).Mycoplasma pneumoniae,Streptococcus pneumoniae,and Influenza A virus were the three most common pathogens in the pre-outbreak CAP group.In the post-outbreak community-acquired pneumonia,Influenza B virus,Klebsiella pneumoniae and Streptococcus pneumoniae were the three most common pathogens.The incidence of Influenza A virus,Parainflluenza virus,and Mycoplasma pneumoniae was significantly higher in the pre-outbreak period than in the post-outbreak period,and the differences between the two groups were statistically significant(all P＜0.05).Conclusion Before and after the epidemic,viral infection are the main pathogens of CAP patients,which is of great significance for future empirical treatment,protection of susceptible population and control of infectious diseases.关键词
新型冠状病毒感染/发热门诊/社区获得性肺炎/病原谱Key words
novel coronavirus infection/fever clinic/community acquired pneumonia/spectrum of pathogens分类
医药卫生引用本文复制引用
程然,李璐,李晓光,路明,林菲..新型冠状病毒感染疫情前后成人社区获得性肺炎病原谱变化及分析[J].中国临床药理学杂志,2024,40(4):607-610,4.基金项目
国家科技重大专项课题艾滋病和病毒性肝炎等重大传染病防治基金资助项目(2017ZX10103004) （2017ZX10103004）
