中国临床药理学杂志2024，Vol.40Issue(4)：615-618,4.DOI:10.13699/j.cnki.1001-6821.2024.04.029
新型淋巴示踪剂—示踪用盐酸米托蒽醌注射液
A novel self-assembly lymphatic tracer—"mitoxantrone hydrochloride injection for tracing"
摘要
Abstract
Standardized lymph node dissection is the key to radical surgery for malignant tumors.However,the choice of lymphatic tracers in China is limited at present.After years of research and development,the team of Shujun Wang from Shenyang Pharmaceutical University has innovatively developed the first biological self-assembly nanocrystal lymphatic targeted tracer——mitoxantrone hydrochloride injection for tracing.After preclinical animal studies and phase Ⅰ-Ⅲ clinical studies,the drug was approved for marketing in China in June 2021 and it has been widely used in lymph node dissection for thyroid cancer and sentinel lymph node biopsy for breast cancer.Its efficacy and safety have been clinically verified.This article expounds the mechanism of action,method of application,efficacy and safety,pharmacokinetics,and differences from traditional mitoxantrone used in chemotherapy,so as to provide a reference for the clinical application of mitoxantrone hydrochloride injection for tracing.关键词
示踪用盐酸米托蒽醌注射液/纳米晶体/淋巴示踪剂/乳腺癌/甲状腺癌Key words
mitoxantrone hydrochloride injection for tracing/nanocrystals/lymphatic tracer/breast cancer/thyroid cancer分类
医药卫生引用本文复制引用
郎罡,李馨颐,王淑君..新型淋巴示踪剂—示踪用盐酸米托蒽醌注射液[J].中国临床药理学杂志,2024,40(4):615-618,4.基金项目
国家"十三五"重大新药创制科技重大专项成果转化 （）
