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乳腺癌根治手术关键问题OA北大核心CSTPCD

Key issues of radical surgery for breast cancer

中文摘要英文摘要

1894年Halsted报道切除全部乳腺、胸大、小肌联合腋窝淋巴结清扫的乳腺癌根治手术使乳腺癌病人5年生存率达到40%.历时近130年,Halsted手术方式作为肿瘤经典根治术载入乳腺癌外科的历史.20世纪70年代,以提高生存质量为目的的Patey,Auchincloss等改良根治手术方式,以Halsted术式为对照组完成了生存获益的非劣效研究,并成为70%以上中国早期乳腺癌病人接受的常规手术方式.进入21世纪以来,伴随乳腺癌诊治理念的更新,保留乳房手术联合放疗,前哨淋巴结活检阴性豁免腋窝淋巴结清扫所带来的临床获益得到广泛认同.乳腺癌根治性手术的基本理念也被赋予了新的内涵.科学解读乳腺癌根治性手术的基本定义和基本问题是推动并提高乳腺癌临床同质化诊疗水平的关键.

In 1894,Halsted described radical mastectomy could improve 5-year survival of patients with breast cancer to 40%operation by removal of breast,axillary lymph nodes and both pectoralis muscles.For the later 130 years,Halsted radi-cal mastectomy had been recorded in the history of breast sur-gery as a classical radical operation.In 1970 s,modified radi-cal mastectomy of Patey or Auchincloss,which improved the quality of patients'life,was proved no inferior to Halsted radi-cal mastectomy in survival benefits,and became the most com-mon procedure implemented for more than 70%patients with breast cancer in China.Since the beginning of 21st century,with the renewal of the concept of diagnosis and treatment of breast cancer,breast conserving-surgery combined with radio-therapy,omitting axillary lymph node dissection if sentinel lymph node is negative,have been widely recognized for their clinical benefits.The concept of radical surgery for breast can-cer has been updated.Scientific interpretation of radical sur-gery for breast cancer is the key to promote clinical homogeni-zation for diagnosis and treatment of breast cancer.

刘荫华;周思成;向泓雨;辛灵

北京大学第一医院甲状腺乳腺外科,北京 100034

临床医学

乳腺外科根治性手术规范化诊治

breast cancerradical surgerystandardized diagnosis and treatment

《中国实用外科杂志》 2024 (001)

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北京奖励基金会项目(No.YXJL-2020-0941-0736);中国乳腺外科青年医师研究项目(No.2020-CHPASLP-01,No.CJBSRAF-2022)

10.19538/j.cjps.issn1005-2208.2024.01.05

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