中国畜牧杂志2024，Vol.60Issue(2)：64-70,7.DOI:10.19556/j.0258-7033.20230207-06
纳米颗粒在配子及胚胎生物技术中的应用研究进展
Advances in the Application of Nanoparticles in Gametes and Embryonic Biotechnology
摘要
Abstract
Assisted reproductive technology(ART)holds significant promise for infertility diagnosis and treatment,endangered species preservation,rapid and efficient propagation of superior varieties.Although ART has been routinely performed and applied worldwide,it also faces some challenges,such as the suboptimal efficacy of the technique.It is demonstrated that gametes and embryos are under oxidative stress during non-physiological culture and preservation,and a growing body of evidence indicates that oxidative stress is mainly accounted for the decreased sperm capacitation as well as the compromised developmental potential in oocyte and embryos.In recent years,decreased oxidative stress level in gametes as well as improved efficiency of in embryo biotechnology has been achieved by the innovative application of nanoparticle(NPs)related technologies and schemes.In the present article,the entry mode and distribution of NPs as well as the influencing factors are systematically analyzed.Moreover,the mechanism underlying the action of NPs is discussed in depth.Finally,the current application progress of NPs in gametes,in vitro embryo production and cryopreservation is summarized,with the purpose to provide a new method and theoretical basis for improving the overall efficiency of ART.关键词
纳米颗粒/配子/胚胎/体外胚胎生产/低温保存/氧化应激Key words
Nanoparticle/Gamete/Embryo/In vitro embryo production/Cryopreservation/Oxidative stress分类
农业科技引用本文复制引用
海桂萍,李俊,刘倩,刘昱成,万鹏程,阿布力孜·吾斯曼,傅祥伟..纳米颗粒在配子及胚胎生物技术中的应用研究进展[J].中国畜牧杂志,2024,60(2):64-70,7.基金项目
中央引导地方科技发展资金项目(纳米颗粒 3D、226Z7713G) （纳米颗粒 3D、226Z7713G）
兵团科技发展专项(S2021BC505) （S2021BC505）
河北省政府资助临床医学优秀人才培养项目 （）
