中国药科大学学报2024，Vol.55Issue(1)：5-14,10.DOI:10.11665/j.issn.1000-5048.2023112702
靶向PD-1/PD-L1的新策略:降解剂、双功能分子及共价抑制剂
New strategies for targeting PD-1/PD-L1:degraders,bifunctional molecules and covalent inhibitors
摘要
Abstract
Programmed cell death protein-1(PD-1)/programmed cell death ligand-1(PD-L1)has been considered to be one of the most promising targets for tumor immunotherapy.At present,both monoclonal antibody drugs and small molecule inhibitors targeting PD-1/PD-L1 are facing bottlenecks.Numerous researchers have tried to explore different strategies to block the PD-L1/PD-L1 pathway,hoping to improve the effects of tumor immunotherapy.This review focuses on the degraders,bifunctional molecules and covalent inhibitors that target PD-L1,aiming to provide inspiring insights for the development of anti-PD-1/PD-L1 drugs.关键词
PD-1/PD-L1/肿瘤免疫/降解剂/双功能分子/共价抑制剂Key words
PD-1/PD-L1/tumor immunotherapy/degraders/bifunctional molecules/covalent inhibitors分类
医药卫生引用本文复制引用
王志杰,廖晓彤,郭霞,陈建军..靶向PD-1/PD-L1的新策略:降解剂、双功能分子及共价抑制剂[J].中国药科大学学报,2024,55(1):5-14,10.基金项目
This study was supported by the National Natural Science Foundation of China(No.82173668,No.82373706)国家自然科学基金项目(No.82173668,No.82373706) （No.82173668,No.82373706）
