不同剂量甲苯磺酸瑞马唑仑在老年全身麻醉手术患者麻醉诱导中的应用效果OA

Objective To explore the effect of different doses of Vamorolone on anesthesia induction in elderly patients undergoing general anesthesia.Methods A total of 120 elderly patients undergoing general anesthesia in Huangshi Aikang Hospital affiliated to Hubei Institute of Technology were selected as the study subjects.All of them were anesthetized with rimazolam toluene sulfonate,and were divided into low-dose group(0.2 mg/kg),medium-dose group(0.3 mg/kg)and high-dose group(0.4 mg/kg)with 40 cases in each group by random number table method.Hemodynamic parameters(heart rate(HR),mean arterial pressure(MAP),arterial oxygen saturation(SaO2)),quality of anesthesia induction and recovery,depth of sedation(BIS value,modified vigilance/Sedation score(MOAA/S))and adverse reactions were compared among the 3 groups.Results There was no significant difference in MAP and SaO2 between 3 groups before anesthesia induction and after tracheal intubation(P＞0.05).After endotracheal intubation,HR in medium and high dose groups was significantly lower than that in low dose group(P＜0.05),but there was no significant difference in HR between medium dose group and high dose group(P＞0.05).The onset time of anesthesia in medium and high dose groups was significantly shorter than that in low dose group(P＜0.05),and the eye opening time,extubation time and PACU residence time in low and medium dose groups were significantly shorter than that in high dose group(P＜0.05).There was no statistical significance in eye opening time,extubation time and PACU residence time between low dose group and medium dose group(P＞0.05).There were no significant differences in BIS and MOAA/S scores among the three groups before anesthesia induction(P＞0.05).After endotracheal intubation,BIS value in medium-dose group and high-dose group was significantly lower than that in low-dose group(P＜0.05),and MOAA/S score was significantly higher than that in low-dose group(P＜0.05).There was no statistical significance in BIS value and MOAA/S score between medium-dose group and high-dose group(P＞0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion In elderly patients undergoing general anesthesia surgery,0.3 mg/kg remimazolam tosilate for general anesthesia induction has stable hemodynamic indicators,high quality of anesthesia and recovery and ideal depth of sedation.