中国药科大学学报2024，Vol.55Issue(1)：15-25,11.DOI:10.11665/j.issn.1000-5048.2023112402
cGAS-STING信号通路调节剂在免疫治疗中的研究进展
Research progress of cGAS-STING signaling pathway modulators in immunotherapy
摘要
Abstract
Upon monitoring cytoplasmic aberrant double-stranded DNA,cGAS-STING signaling pathway induces the expression of type I interferons and pro-inflammatory cytokines,which activates the host immune response and enhances anti-tumor immune response and resistance to pathogen infection.However,sustained activation of the cGAS-STING signaling pathway drives diseases such as autoimmune diseases,aging-associated inflammation,and neurodegenerative pathologies.Herein,we describe the mechanism by which cGAS-STING signaling pathway participates in regulating the development of various immune-related diseases,with a particular review of the research and development progress of STING agonists,cGAS inhibitors,and STING inhibitors,aiming to provide some theoretical reference for the future development of cGAS-STING modulators.关键词
cGAS-STING信号通路/STING激动剂/cGAS抑制剂/STING抑制剂/免疫治疗Key words
cGAS-STING signaling pathway/STING agonist/cGAS inhibitor/STING inhibitor/immunotherapy分类
医药卫生引用本文复制引用
娄方宁,郑明月,陈凯先,张素林..cGAS-STING信号通路调节剂在免疫治疗中的研究进展[J].中国药科大学学报,2024,55(1):15-25,11.基金项目
This study was supported by the National Natural Science Foundation of China(No.T2225002,No.82273855) （No.T2225002,No.82273855）
the National Key Research and Development Program of China(No.2022YFC3400504) （No.2022YFC3400504）
CAS Youth Innovation Promotion Association(No.2023296) （No.2023296）
and the Natural Science Foundation of Shanghai(No.22ZR1474300)国家自然科学基金项目(No.T2225002 （No.22ZR1474300）
82273855) （）
国家重点研发计划项目(No.2022YFC3400504) （No.2022YFC3400504）
中国科学院青年创新促进会资助项目(No.2023296) （No.2023296）
上海市自然科学基金项目(No.22ZR1474300) （No.22ZR1474300）
