中国药科大学学报2024，Vol.55Issue(1)：26-35,10.DOI:10.11665/j.issn.1000-5048.2023120201
具有抗肿瘤免疫治疗作用的铂类药物研究进展
Research progress on the antitumor effects of platinum-based chemo-immunotherapies
摘要
Abstract
As potential immunomodulators,platinum-based drugs could trigger immunogenic cell death(ICD).Hence,combination of platinum-based chemotherapy and immunotherapy could have better synergistic anticancer effect.Pt(Ⅱ)-based drugs are the most common chemotherapeutic agents in cancer treatment yet with limited clinical application due to their toxic side-effects and drug resistance.Pt(Ⅳ)complexes have been widely investigated in the past decades due to their kinetic inertness and unique mechanisms.This article summarizes the progress in the pharmacological activities and mechanisms of Pt(Ⅳ)antitumor complexes via introducing different immunomodulators into chemotherapeutic agents in literature over recent years and highlights the potential targets and molecular signaling pathways so as to provide some reference for further development and potential clinical application of platinum-based chemo-immunotherapeutic agents.关键词
免疫调节药物/铂(Ⅱ)药物/铂(Ⅳ)配合物/联合用药/免疫化学疗法Key words
immunomodulators/platinum(Ⅱ)-based drugs/platinum(Ⅳ)complexes/combined drug therapy/chemo-immunotherapy分类
医药卫生引用本文复制引用
陈飞虹,赵德明,苟少华..具有抗肿瘤免疫治疗作用的铂类药物研究进展[J].中国药科大学学报,2024,55(1):26-35,10.基金项目
This study was supported by the National Natural Science Foundation of China(No.21571033,No.82173852)国家自然科学基金项目(No.21571033,No.82173852) （No.21571033,No.82173852）
