中国药科大学学报2024，Vol.55Issue(1)：45-52,8.DOI:10.11665/j.issn.1000-5048.2023112903
靶向蛋白S-棕榈酰化修饰在T细胞免疫疗法中的研究进展
Research progress on targeted protein S-palmitoylation modification in T cell immunotherapy
孙丽婷 1张为国 2童玥3
作者信息
- 1. 中国药科大学生命科学与技术学院, 南京 211198||中国医学科学院北京协和医学院苏州系统医学研究所, 苏州 215123
- 2. 中国医学科学院北京协和医学院苏州系统医学研究所, 苏州 215123
- 3. 中国药科大学生命科学与技术学院, 南京 211198
- 折叠
摘要
Abstract
S-palmitoylation,a reversible and dynamic post-translational modification in cells,is involved in regulating the transcription and expression of downstream target genes as well as signal transduction,thereby affecting cell life activities.Studies have shown that thousands of human proteins undergo S-palmitoylation modification,suggesting that S-palmitoylation is closely related to the progression and treatment of diseases.T cells play central roles in anti-tumor immune responses.A variety of T cell immune-related proteins are regulated by S-palmitoylation.In the present study,we focus on the impact of S-palmitoylation on T cell signal transduction and its application in T cell immunotherapy,aiming to provide new ideas for the development of new targets and peptide inhibitors for T cell immunotherapy.关键词
S-棕榈酰化/DHHC/T细胞/免疫疗法/肽抑制剂Key words
S-palmitoylation/DHHC/T cells/immunotherapy/peptide inhibitors分类
医药卫生引用本文复制引用
孙丽婷,张为国,童玥..靶向蛋白S-棕榈酰化修饰在T细胞免疫疗法中的研究进展[J].中国药科大学学报,2024,55(1):45-52,8.
