糖皮质激素口服给药和经鼻腔雾化吸入用于慢性鼻窦炎患者功能性鼻窦内镜手术后的效果OA

Objective To explore the effects of oral administration of glucocorticoids and nasal nebulization after functional endoscopic sinus surgery in patients with chronic sinusitis.Methods Sixty patients with chronic sinusitis diagnosed in Suzhou Pingjiang Hospital from December 2019 to December 2022 were selected as the study objects.According to the order of treatment,the patients were numbered(1～60)and orally administered prednisone acetate tablets(No.1 to 30).No.31 to 60,Fluticasone propionate was inhaled by aerosol suspension through the nasal cavity(atomization group).The therapeutic effect of the two groups was compared.Results The cure rate of atomization group was slightly higher than that of oral group,but there was no significant difference between groups(P＞0.05).After 2 weeks of treatment,the Lnud-Kenndry score of nasal endoscopy in 2 groups was decreased,and the nebulizer group was lower than the oral group,the difference was statistically significant(P＜0.05).After 2 weeks of treatment,the serum glucocorticoid level in the oral group was significantly decreased(P＜0.05),while the serum glucocorticoid level in the atomized group was significantly higher than that in the oral group(P＜0.05),while the serum glucocorticoid level in the atomized group was significantly higher than that before treatment(P＜0.05).The incidence of adverse reactions in atomization group was lower than that in oral group,and the difference was statistically significant(P＜0.05).Conclusion The application of glucocorticoids through nasal atomization in patients undergoing functional endoscopic sinus surgery for chronic sinusitis is more conducive to postoperative sinus mucosal recovery and has higher safety.