中国药理学与毒理学杂志2024，Vol.38Issue(2)：128-136,9.DOI:10.3867/j.issn.1000-3002.2024.02.007
神经调控技术在脑科学研究中的应用研究进展
Advances in applications of neuroregulatory techniques in research on brain sciences
摘要
Abstract
Drugs and physical stimulation,including light,electricity,and magnetic fields,can be used to influence how neurons operate,among which chemogenetic and optogenetic technologies are most widely used.In recent years,magnetogenetic technology has also been developed that can acti-vate neurons in magnetic fields through magnetic sensitive actuators,leading to non-invasive and instanta-neous activation of specific brain regions.This article reviews the evolution of and problems with chemoge-netic and optogenetic techniques commonly used in brain science research.It also outlines the latest progress in magnetogenetic technologies,which are not full-fledged yet,as well as the role of transcra-nial electrical stimulation,transcranial magnetic stimulation,deep brain stimulation and transcranial ultra-sound stimulation technology in the functional regulation of brain diseases.Constant adjustment and improvement can make it possible for these technologies to be used more widely for the study of brain sciences and the treatment of brain diseases.关键词
脑科学/精神疾病/光遗传技术/化学遗传技术/磁遗传技术Key words
brain science/mental disorders/optogenetic technology/magnetogenetic technology/chemogenetic technology分类
医药卫生引用本文复制引用
刘梦楠,田萧羽,李奕潼,吴宁,李锦,李红..神经调控技术在脑科学研究中的应用研究进展[J].中国药理学与毒理学杂志,2024,38(2):128-136,9.基金项目
国家自然科学基金(81973303) （81973303）
国家自然科学基金(82202523) National Natural Science Foundation of China(81973303) （82202523）
and National Natural Science Foundation of China(82202523) （82202523）
