胰腺癌耐药性机制的研究现状OA北大核心CSTPCD
Research status on the mechanism of drug resistance in pancreatic cancer
胰腺癌(PC)属于消化道恶性肿瘤,早期难诊断,易转移和复发,对常规的放化疗有耐药性,是非常难治疗的疾病.PC耐药性的关键调节因子如上皮间-充质转换表型细胞、肿瘤干细胞、miRNA对耐药性机制产生的作用以及相关治疗策略早已在前些年有过相关综述,现如今新的一些调节因子已被发现,作为补充.本文侧重综述了 PC化疗耐药性的关键调节因子(包括长非编码核糖核酸、核转录因子κB以及外泌体)的特征和性质、耐药性机制以及相关治疗策略,并对未来的治疗方向进行了预测和展望.
Objective Pancreatic cancer(PC)is a malignant tumor of the digestive tract that is difficult to diagnose early,easily metastasizes and relapses,and resistant to conventional chemotherapy.PC is a very difficult disease to treat.The key regulatory factors of PC resistance,such as epithelial-mesenchymal transition phenotypic cells,tumor stem cells,and miRNAs,have been reviewed in the past few years,and some new regulatory factors have been discovered as supplements.This review mainly focuses on the characteristics and properties of the key regulatory factors of PC chemotherapy resistance including long noncoding RNAs,nuclear factor KB and exosomes,drug resistance mechanisms,and treatment related strategies,and future treatment directions were predicted.
陈莞沁;关秋彤;黄晓娴;魏敏杰;李振华
中国医科大学药学院药理教研室,辽宁沈阳 110122
药学
胰腺癌耐药性化疗机制调节因子
pancreatic cancerdrug resistancechemotherapymechanismmodulator
《中国临床药理学杂志》 2024 (003)
454-458 / 5
中国医科大学引进人才启动基金资助项目(1210619010);中国医科大学"双一流"建设专项基金资助项目(3110210603)
评论