|国家科技期刊平台
首页|期刊导航|中国康复理论与实践|经颅直流电刺激对帕金森病患者认知功能和生活质量影响的Meta分析

经颅直流电刺激对帕金森病患者认知功能和生活质量影响的Meta分析OA北大核心CSTPCD

Effect of transcranial direct current stimulation on cognitive function and quality of life in patients with Parkin-son's disease:a meta-analysis

中文摘要英文摘要

目的 评估经颅直流电刺激(tDCS)对帕金森病患者认知功能和生活质量的影响. 方法 检索PubMed、Web of Science、Embase、Cochrane Library、中国知网、中国生物医学文献数据库、维普和万方数据库,纳入有关tDCS治疗帕金森病患者的随机对照试验.对照组接受如普拉克索等常规抗帕金森病药物治疗或tDCS假刺激、理疗、认知康复训练等,治疗组在对照组基础上加用tDCS.检索时间为建库至2023年9月.采用Cochrane偏倚风险评估工具对研究质量进行评价,利用RevMan 5.4和Stata 17.0进行数据合并和分析,并分析异质性和敏感性. 结果 共纳入8篇文献.tDCS能够显著提高帕金森病患者蒙特利尔认知评估量表评分(MD = 2.00,95%CI 1.13~2.87,P<0.001),但帕金森病患者生活质量评分(MD = 0.73,95%CI-5.78~7.23,P = 0.830)、贝克抑郁自评量表评分(MD =-0.77,95%CI-7.14~5.60,P = 0.810)和统一帕金森病评定量表第三部分评分(MD = 1.60,95%CI-0.77~3.97,P = 0.190)无显著性变化. 结论 tDCS能促进帕金森病患者认知功能改善.

Objective To evaluate the effect of transcranial direct current stimulation(tDCS)on the cognitive function and quality of life in patients with Parkinson's disease. Methods Randomized controlled trials(RCTs)on tDCS for Parkinson's disease were searched in PubMed,Web of Sci-ence,Embase,Cochrane Library,CNKI,CBM,VIP and Wanfang Data from the inception to September,2023.Control group was administered standard Parkinson's medications or placebo,physical therapy,and cognitive re-habilitation,while treatment group received tDCS additionally.The quality of the researches was evaluated using the Cochrane Risk of Bias Tool.Data synthesis and analysis were performed using RevMan 5.4 and Stata 17.0,with heterogeneity and sensitivity analyses. Results Eight articles were included.tDCS significantly improved the scores of Montreal Cognitive Assessment(MD = 2.00,95%CI 1.13 to 2.87,P<0.001).However,there was no significant difference in the scores of Parkinson's Disease Questionnaire(MD = 0.73,95%CI-5.78 to 7.23,P = 0.830),Beck Depression Inventory-Ⅱ(MD =-0.77,95%CI-7.14 to 5.60,P = 0.810),and Unified Parkinson Disease Rating Scale-Ⅲ(MD = 1.60,95%CI-0.77 to 3.97,P = 0.190). Conclusion tDCS may improve cognitive function of patients with Parkinson's disease.

王铭琛;张文宇;张贤祚;臧万里

山东中医药大学第一临床医学院,山东济南市 250014中国科学技术大学附属第一医院骨科,安徽合肥市 230026哈尔滨体育学院研究生院,黑龙江哈尔滨市 150008

临床医学

帕金森病认知障碍经颅直流电刺激Meta分析

Parkinson's diseasecognitive impairmenttranscranial direct current stimulationmeta-analysis

《中国康复理论与实践》 2024 (002)

183-188 / 6

国家自然科学基金项目(No.82202672) National Natural Science Foundation of China(No.82202672)

10.3969/j.issn.1006-9771.2024.02.007

评论