中国临床药理学杂志2024，Vol.40Issue(4)：483-486,4.DOI:10.13699/j.cnki.1001-6821.2024.04.001
二甲双胍对奥氮平治疗精神分裂症患者糖脂代谢及肾功能的影响
Effects of metformin on glucolipid metabolism and renal function in patients with schizophrenia after olanzapine treatment
摘要
Abstract
Objective To explore the effects of metformin on glucolipid metabolism and renal function in patients with schizophrenia(SCH)after olanzapine treatment.Methods A retrospective analysis was performed on the case data of patients with metabolic syndrome induced by metformin and olanzapine treatment by cohort method.On basis of routine treatment(olanzapine,initial dose:10 mg·d-1,maximum dose≤ 20 mg·d-1),patients in high-dose group were given oral metformin tablets 750 mg(qd),while patients in low-dose group were given metformin tablets 250 mg(qd)for 1 month.The levels of fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)before treatment and at 1 month after treatment,and safety evaluation were compared between the two groups.Results 43 cases in the high-dose group and 37 cases in the low-dose group.After treatment,FPG levels in low-dose group and high-dose group were(4.25±1.07)and(3.81±0.72)mmol·L-1,HbA1c levels were(5.10±0.54)％and(4.86±0.41)％,TC levels were(4.22±0.49)and(3.29±0.68)mmol·L-1,TG levels were(1.93±0.32)and(1.05±0.27)mmol·L-1,LDL-C levels were(3.26±0.68)and(2.89±0.43)mmol·L-1,HDL-C levels were(0.92±0.27)and(1.27±0.35)mmol·L-1,BUN levels were(4.71±0.90)and(5.08±1.49)mmol·L-1,Cr levels were(61.28±9.71)and(65.43±9.26)μmol·L-1,β2-MG levels were(1.72±0.46)and(1.97±0.55)μg·L-1,CRP levels were(6.20±0.87)and(10.85±1.42)mg·L-1,TNF-αlevels were(726.49±201.26)and(1 030.14±253.97)pg·mL-1,and the differences were statistically significant(all P＜0.05).The incidence of adverse drug reactions in high-dose group was higher than that in low-dose group(32.56％vs 13.51％,P＜0.05).Conclusion Metformin can effectively improve glucolipid metabolism and renal function in SCH patients after olanzapine treatment.Low-dose metformin has higher treatment safety.关键词
二甲双胍/奥氮平/代谢综合征/精神分裂症/糖脂代谢/肾功能Key words
metformin/olanzapine/metabolic syndrome/schizophrenia/glycolipid metabolism/renal function分类
医药卫生引用本文复制引用
刘静,辜炜君,巫斌..二甲双胍对奥氮平治疗精神分裂症患者糖脂代谢及肾功能的影响[J].中国临床药理学杂志,2024,40(4):483-486,4.基金项目
厦门市仙岳医院科研立项基金资助项目(2020XYYB10) （2020XYYB10）
