中国医学创新2024，Vol.21Issue(5)：46-50,5.DOI:10.3969/j.issn.1674-4985.2024.05.011
瑞马唑仑对肝切除术患者术后苏醒质量及认知功能的影响
Effects of Remimazolam on Recovery Quality and Postoperative Cognitive Dysfunction in Patients with Hepatectomy
摘要
Abstract
Objective:To observe the effects of Remimazolam on postoperative recovery quality and cognitive function in patients with hepatectomy,and to discuss its clinical value.Method:A total of 60 patients requiring hepatectomy admitted to the First Affiliated Hospital of Gannan Medical University from January 2022 to August 2023 were randomly divided into two groups.The control group was induced by Propofol,Fentanyl,Cisatracurium,and anesthesia maintained by pump injection of Propofol and Remifentanil.The observation group was induced by intravenous Remimazolam Tosilate,Fentanyl and Cisatracurium,and maintained by pump injection of Remimazolam Tosilate and Remifentanil.The vital signs,recovery quality indexes and postoperative cognitive function of the two groups were compared.The levels of plasma central nerve specific proteins(S100β)and neuron-specific enolase(NSE)were measured and the incidence of adverse reactions was statistically analyzed.Result:The mean arterial pressure(MAP)and heart rate(HR)after entry(T0),after anesthesia induction(T1),skin resection(T2),1 h after operation(T3),at the end of operation(T4),at the time of tracheal catheter removal(T5),and at leaving the recovery room(T6)had no significant differences,and MMSE scores,plasma S100β and NSE levels preoperative 1 d,postoperative 1 d,and postoperative 3 d had no significant differences(P>0.05);the HR level of the observation group at T5 was higher than that at T0,the difference was statistically significant(P<0.05).Respiratory recovery time,eye opening time,extubation time and recovery room residence time in the observation group were earlier or lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group(10.0%)was lower than that(33.3%)in the control group,the difference was statistically significant(P<0.05).Conclusion:Remimazolam can be used in patients undergoing hepatectomy with shorter recovery time,and it does not affect cognitive function,and lower incidence of adverse reactions.关键词
瑞马唑仑/肝切除术/苏醒质量/认知功能Key words
Remimazolam/Hepatectomy/Awakening quality/Cognitive function引用本文复制引用
卓明,刘金龙,钟茂林,王辉,黄可女,叶军明..瑞马唑仑对肝切除术患者术后苏醒质量及认知功能的影响[J].中国医学创新,2024,21(5):46-50,5.基金项目
赣州市2021年指导性科技计划项目(GZ2021ZSF076) （GZ2021ZSF076）
