中国临床药理学杂志2024，Vol.40Issue(4)：497-500,4.DOI:10.13699/j.cnki.1001-6821.2024.04.004
吲哚布芬联合氯吡格雷对急性心肌梗死患者PCI术后疗效的临床研究
Clinical study on the curative effect of indobufen combined with clopidogrel in patients with acute myocardial infarction after PCI
摘要
Abstract
Objective To explore the curative effect of indobufen combined with clopidogrel and its influences on platelet activity and coagulation function in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods According to different treatment methods,patients with AMI were divided into treatment group and control group.The control group was given clopidogrel(75 mg,qd)and aspirin(0.1 g,qd),while treatment group was given clopidogrel(75 mg,qd)and indobufen tablets(0.1 g,bid).All were treated for 1 month.The curative effect,platelet count(PLT),mean platelet volume(MPV),prothrombin time(PT),fibrinogen(FIB)and D-dimer(D-D)before and after treatment,and adverse events within 1 month after medication were compared between the two groups.Results There were 38 cases in treatment group and 43 cases in control group.After treatment,curative effect in treatment group and control group were 97.37％and 86.05％,PLT were(167.89±43.62)× 109·L-1 and(183.73±49.81)× 109·L-1,MPV were(11.86±2.31)and(10.97±2.16)fl,FIB levels were(2.53±0.61)and(2.78±0.72)g·L-1,D-D levels were(0.20±0.06)and(0.22±0.07)mg·L-1,PT were(12.82±2.35)and(12.26±2.28)s,the difference was not statistically significant(all P＞0.05).The incidence of adverse drug reactions in treatment group and control group were 2.63％and 11.63％,and the difference was statistically significant(P＜0.001).Conclusion Indobufen combined with clopidogrel has the comparable curative effect and good anti-platelet aggregation effect as aspirin,and indobufen has higher safety.So it is recommended as the medication regimen for AMI patients after PCI.关键词
吲哚布芬/氯吡格雷/急性心肌梗死/经皮冠状动脉介入治疗/临床疗效/血小板活性/凝血功能Key words
indobufen/clopidogrel/acute myocardial infarction/percutaneous coronary intervention/curative effect/platelet activity/coagulation function分类
医药卫生引用本文复制引用
程辉,彭杰成,伍万仕,胡兴兵,苏家凤..吲哚布芬联合氯吡格雷对急性心肌梗死患者PCI术后疗效的临床研究[J].中国临床药理学杂志,2024,40(4):497-500,4.基金项目
2022年安徽医科大学校科研基金资助项目(2022xkj229) （2022xkj229）
