中国临床药理学杂志2024，Vol.40Issue(4)：505-509,5.DOI:10.13699/j.cnki.1001-6821.2024.04.006
地诺孕素联合左炔诺孕酮宫内节育系统治疗子宫内膜异位症患者的临床研究
Clinical trial of dinorgestrel combined with levonorgestrel intrauterine birth control system in treatment of patients with endometriosis
摘要
Abstract
Objective To study the effect of dinorgestrel combined with levonorgestrel intrauterine birth control system in the treatment of endometriosis(EMs)and its effect on endometrial thickness and hormone levels.Methods EMs patients were selected as the research objects and divided into treatment group and control group according to the cohort method.Patients in the control group were treated with levonorgestrel intrauterine birth control system,while patients in the treatment group were treated with dinorgestrel on the basis of the control group.Compared the efficacy of two groups of patients before and after treatment,use visual analogue scale(VAS)to score pain,calculate endometrial thickness based on menstrual blood to sanitary napkin area,and use radioimmunoassay to measure changes in hormone levels[follicle stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),prolactin(PRL),and progesterone(P)]in vivo.Results The control group and the treatment group were enrolled in 40 patients.The total effective rates of treatment in the control group and the treatment group were 75％and 95％,respectively.After treatment,the scores of dysmenorrhea in 2 groups were 3.27±1.04 and 1.36±0.69;the scores of dyspareunia pain were 2.42±0.89 and 1.04±0.55;the scores of abdominal pain in non-menstrual period were 2.17±1.25 and 1.49±1.03,respectively;endometrial thickness were(6.02±1.25)and(3.64±1.04)mm;hemoglobin concentration were(106.58±12.07)and(112.85±12.37)g·L-1;menstrual volume score were 38.41±15.21 and 12.41±4.81;FSH levels were(3.89±2.19)and(2.52±1.30)U·L-1;LH levels were(6.90±2.92)and(8.51±3.72)U·L-1;PRL levels were(367.98±77.99)and(322.01±57.95)μg·L-1;E2 levels were(548.67±79.38)and(504.92±61.31)pmol·L-1;P levels were(17.69±7.38)and(12.23±6.61)nmol·L-1,respectively.Compared with control group,the above indexes in treatment group were statistically significant(all P＜0.05).The adverse drug reactions in the treatment group were mainly vaginal bleeding,fever and vertigo,the adverse drug reactions in the control group were mainly bleeding,fever and vertigo.The total incidence of adverse drug reactions in treatment group and control group was 12.50％and 10.00％,respectively,with no statistically significant difference(P＞0.05).Conclusion The combination of dexamethasone and dexamethasone has a significant therapeutic effect on endometriosis,reducing endometrial thickness and optimizing hormone levels.关键词
地诺孕素/左炔诺孕酮宫内节育系统/子宫内膜异位症/子宫内膜厚度/激素Key words
dinorgestrel/levonorgestrel intrauterine birth control system/endometriosis/endometrial thickness/hormones分类
医药卫生引用本文复制引用
郭立文,高琛,陈锦果,陈子春..地诺孕素联合左炔诺孕酮宫内节育系统治疗子宫内膜异位症患者的临床研究[J].中国临床药理学杂志,2024,40(4):505-509,5.基金项目
福建省自然科学基金资助项目(NO:2020J011342) （NO:2020J011342）
宁德师范学院文件基金资助项目(宁师科院[2023]8号(2023T12)) （宁师科院[2023]8号(2023T12）
