中国临床药理学杂志2024，Vol.40Issue(4)：519-523,5.DOI:10.13699/j.cnki.1001-6821.2024.04.009
不同雄激素阻断方案治疗晚期前列腺癌患者疗效的临床研究
Clinical study on efficacy of different androgen deprivation regimens in the treatment of advanced prostate cancer
罗怀景 1张婷婷 2董兴模 1林超禄 1余丰1
作者信息
- 1. 福建医科大学附属龙岩第一医院泌尿外科,福建龙岩 364000
- 2. 福建医科大学附属龙岩第一医院超声科,福建龙岩 364000
- 折叠
摘要
Abstract
Objective To compare the application effect of intermittent androgen deprivation(IAD)and continued androgen deprivation(CAD)on advanced prostate cancer and influence on prognosis.Methods The patients with advanced prostate cancer were divided into treatment group(86 cases)and control group(62 cases)according to the cohort method.The treatment group was given IAD regimen(subcutaneous injection of 3.6 mg goserelin once every 28 days)combined with oral administration of flutamide(250 mg every 3 times a day)or combined with oral administration of bicalutamide(50 mg once a day),and the control group was treated with CAD regimen(bilateral orchiectomy combined with continuous flutamide or bicalutamide orally,with the same dosage as the treatment group).The observation follow-up time of both groups was ≥9 months.Efficacy,serum total testosterone(TT),prostate specific antigen(PSA)and vascular endothelial growth factor(VEGF)were compared between the two groups after treatment,and the side effects of treatment,quality of life[Functional Assessment of Cancer Therapy-Prostate(FACT-P)]and disease progression were evaluated.Results At 9 months after treatment,the objective response rates(ORR)in treatment group and control group were 30.99％(22 cases/71 cases)and 29.09％(16 cases/55 cases),and the disease control rates(DCR)were 71.83％(51 cases/71 cases)and 69.09％(38 cases/55 cases)respectively(P＞0.05).Serum TT levels in treatment group and control group were(25.53±9.44)and(22.51±8.28)ng·dL-1,PSA levels were(4.48±1.02)and(4.32±0.95)ng·mL-1,and VEGF levels were(121.03±35.26)and(118.65±33.42)pg·mL-1 respectively(all P＞0.05).The incidence rates of hot flash in treatment group and control group were 21.13％and 56.36％,the incidence rates of breast swelling pain were 16.90％and 34.55％,and the incidence rates of osteoporosis were 8.45％and 25.45％respectively(all P＜0.05).The scores of physical condition of FACT-P in treatment group and control group were(24.15±4.22)and(20.28±3.71)points,the scores of life condition were(20.28±2.94)and(17.81±2.84)points,scores of prostate cancer specific(PCS)module were(33.21±6.32)and(28.42±5.43)points,respectively,the difference were all statistically significant(all P＜0.05).The cumulative progression-free survival rates in treatment group and control group were 61.97％and 58.18％(P＞0.05).Conclusion IAD is as effective as CAD in the treatment of advanced prostate cancer and has a similar effect on the prognosis of patients,but the former one has fewer side effects of treatment and helps to improve the quality of life of patients.关键词
前列腺癌/间歇性雄激素阻断/持续性雄激素阻断/安全性/预后Key words
prostate cancer/intermittent androgen deprivation/continued androgen deprivation/safety/prognosis分类
医药卫生引用本文复制引用
罗怀景,张婷婷,董兴模,林超禄,余丰..不同雄激素阻断方案治疗晚期前列腺癌患者疗效的临床研究[J].中国临床药理学杂志,2024,40(4):519-523,5.
