中国中医药信息杂志2024，Vol.31Issue(3)：180-185,6.DOI:10.19879/j.cnki.1005-5304.202302459
四神丸治疗溃疡性结肠炎研究进展
Research Progress in the Treatment of Ulcerative Colitis with Sishen Pills
摘要
Abstract
Sishen Pills is a classic prescription for the treatment of spleen and kidney diarrhea,which has the effect of warming the kidney and the spleen,astringent intestine and antidiarrheal.In modern clinical application,the modified prescriptions based on Sishen Pills,combined with other treatments of TCM and integrated traditional Chinese and Western medicine are often used to treat ulcerative colitis with spleen-kidney yang deficiency syndrome,and the curative effect is remarkable.Experimental pharmacological studies have shown that Sishen Pills may achieve the purpose of ulcerative colitis by regulating the expression of related signaling pathway proteins,regulating inflammatory factors,inhibiting inflammatory response,regulating autophagy,regulating intestinal flora,improving intestinal mucosal permeability,repairing intestinal mucosal barrier,regulating cellular energy metabolism,anti-oxidative stress,regulating cellular immune function,etc.In this article,the research status of Sishen Pills in the treatment of ulcerative colitis was sorted out and summarized,in order to provide reference for further study of its mechanism and clinical application.关键词
四神丸/脾肾阳虚/溃疡性结肠炎/作用机制/中医治疗/综述Key words
Sishen Pills/spleen-kidney yang deficiency/ulcerative colitis/mechanism/TCM treatment/review分类
医药卫生引用本文复制引用
李开楊,杨梅,赵琦,黄敬,蔺晓源,刘杰民,郭震凡,石慧,杨月月..四神丸治疗溃疡性结肠炎研究进展[J].中国中医药信息杂志,2024,31(3):180-185,6.基金项目
国家自然科学基金(82060850、82160866) （82060850、82160866）
贵州农村产业革命石斛专项资金项目(黔石科合[2020]004号) （黔石科合[2020]004号）
