中国真菌学杂志2023，Vol.18Issue(6)：487-492,6.
两性霉素B葡萄糖溶液配制及输注方法探索
Preparation and infusion of amphotericin B glucose solution
张俊丽 1蔡诗琪 1方莉 1吕芳芳 1俞云松 1周志慧1
作者信息
- 1. 浙江大学医学院附属邵逸夫医院感染科,杭州 310016||浙江省微生物技术与生物信息学重点实验室,杭州 310016
- 折叠
摘要
Abstract
Objective To analyze the appropriate solvent pH value,final solution concentration of amphotericin B(AmB).Methods Measure the pH value of 5%glucose injection with different specifications,batches.And measure the pH of AmB infusion solution with different concentrations,observe the appearance.Results The pH values of 61.11%of glucose solu-tions with different specifications or batches were not within the preparation requirements of AmB.The pH value of 5%glu-cose of different volume and pH could be adjusted to more than 5.00 by adding 0.1 mL of 5%sodium bicarbonate.The pH value of amphotericin B final solution with the concentration of 4 mg/100 mL-10 mg/100 mL was between 6.00-7.60.The pH value of 250 mL 5%glucose with different concentrations could be adjusted to 6.00-7.50 by adding 0.03-0.15 mL 5%sodium bicarbonate,and no precipitation and crystallization were been seen.Regardless of the initial pH value of glucose so-lution,the pH value of AmB final solution with the concentration of 10 mg/100 mL was 7.10-7.70,and no turbidity was ob-served.Conclusion Pay attention to the pH value of 5%glucose injection before preparation,it was recommended to add buffer if the pH value was less than 4.20.It is recommended that the final concentration of AmB infusion is 4-10 mg/100 mL(≤10 mg/100 mL),in this way,there is no need to adjust the initial pH value of glucose injection.Infusion for 4-8 h was appropriate,but it could be appropriately prolonged for the patients with baseline renal insufficiency,organ transplanta-tion,tumor chemotherapy and other patients with high risk of renal insufficiency.关键词
两性霉素B/堵管现象/5%葡萄糖注射液/5%碳酸氢钠注射液/pH值/输注浓度/输注速度Key words
amphotericin B/pipe blockage/5%glucose injection/5%sodium bicarbonate injection/pH value/infusion con-centration/infusion time分类
医药卫生引用本文复制引用
张俊丽,蔡诗琪,方莉,吕芳芳,俞云松,周志慧..两性霉素B葡萄糖溶液配制及输注方法探索[J].中国真菌学杂志,2023,18(6):487-492,6.
