中国真菌学杂志2023，Vol.18Issue(6)：501-506,524,7.
一种全自动药敏系统检测念珠菌抗真菌药物敏感性的应用评价
Application evaluation of an automatic drug susceptibility system for antifungal susceptibility testing of Can-dida
田瑞卿 1王琦琦 2万喆 2李若瑜 2刘伟2
作者信息
- 1. 北京大学第一医院皮肤性病科,北京大学真菌和真菌病研究中心,北京 100034||保定市第一医院检验科,保定 071000
- 2. 北京大学第一医院皮肤性病科,北京大学真菌和真菌病研究中心,北京 100034
- 折叠
摘要
Abstract
Objective To evaluate the clinical value of a fully automatic fungal drug susceptibility analysis system for in vitro antifungal susceptibility testing of Candida to common antifungal drugs.Methods The susceptibilities of 100 strains of Candida to 9 antifungal drugs were detected by broth microdilution CLSI M27-A4 and automatic fungal drug susceptibility system,and the agreement of the two methods was analyzed.Results The agreement of the two methods is related to the species of Candida and antifungal drugs.When Candida albicans were detected,the essential agreement of caspofungin was 75%.For Candida glabrata,the categorical agreement of caspofungin and voriconazole was 61.1%and 66.7%,respective-ly,and others were 83%～100%.The total essential agreement of 100 Candida to 9 antifungal drugs determined by the two methods was more than 89%,and the total categorical agreement was over 91%.Conclusion The susceptibility of automat-ic fungal drug susceptibility analysis system for Candida in vitro is consistent with CLSI,which has the advantage of rapidi-ty and automation,and has a good application value in clinical microbiology laboratory.关键词
念珠菌属/抗真菌药物敏感性试验/微量肉汤稀释法/全自动真菌药敏Key words
Candida/antifungal susceptibility test/broth microdilution/fully automatic fungal drug susceptibility分类
医药卫生引用本文复制引用
田瑞卿,王琦琦,万喆,李若瑜,刘伟..一种全自动药敏系统检测念珠菌抗真菌药物敏感性的应用评价[J].中国真菌学杂志,2023,18(6):501-506,524,7.
