中国中医药图书情报杂志2024，Vol.48Issue(2)：46-51,6.DOI:10.3969/j.issn.2095-5707.202301029
基于网络药理学探讨芩蓟凉血合剂治疗便秘作用机制
Discussion on the Mechanism of Qinji Liangxue Mixture in the Treatment of Constipation Based on Network Pharmacology
摘要
Abstract
Objective To study the mechanism of Qinji Liangxue Mixture in the treatment of constipation based on network pharmacology.Methods The effective components and action targets in Qinji Liangxue Mixture were obtained from TCMSP and TCMID.Constipation-related targets were retrieved through GeneCards,TTD,DrugBank,OMIM,and DisGeNET databases.The STRING database was used to construct the common target protein-protein interaction(PPI)network PPI.Cytoscape 3.8.1 software was used to construct a network map for the treatment of constipation with Qinji Liangxue Mixture of Chinese materia medica-effective components-disease targets,and key components and core targets were screened.GO analysis and KEGG pathway enrichment analysis of target genes were performed using Metascape platform.Results Five key components(quercetin,kaempferol,luteolin,β-sitosterol,and sterol)and 10 core targets(HSP90AA1,STAT3,MAPK3,TP53,AKT1,MAPK1,RELA,TNF,FOS and IL6)were screened from Qinji Liangxue Mixture.KEGG enrichment analysis showed that target-related pathways for the treatment of constipation were mainly involved in pathways in cancer,lipid and atherosclerosis,calcium signaling pathways,and AMPK signaling pathways.Conclusion Qinji Liangxue Mixture may regulate HSP90AA1,STAT3,MAPK3 and other targets to treat constipation through AMPK,lipid,atherosclerosis and other signaling pathways.关键词
芩蓟凉血合剂/便秘/网络药理学/作用机制Key words
Qinji Liangxue Mixture/constipation/network pharmacology/mechanism分类
医药卫生引用本文复制引用
李鹏,金文琪,李小嘉,胡婕,朱影,郭修田..基于网络药理学探讨芩蓟凉血合剂治疗便秘作用机制[J].中国中医药图书情报杂志,2024,48(2):46-51,6.基金项目
国家自然科学基金(81873308) （81873308）
上海市卫生健康委员会中医药科研项目(2022QN011) （2022QN011）
上海中医药大学产业发展中心医养结合科创项目(YYKC-2021-01-140) （YYKC-2021-01-140）
