中国医学装备2024，Vol.21Issue(2)：12-15,4.DOI:10.3969/j.issn.1672-8270.2024.02.003
18F-FBB PET脑部图像采集中不同时长对感兴趣区域定量参数的影响研究
Research on the effect of different acquisition duration on ROI quantitative parameters in the progress of 18F-FBB PET brain image acquisition
吴世娜 1刘猛 2孙树伟 1常燕 1刘家金 1王瑞民 1徐白萱 1姚树林1
作者信息
- 1. 解放军总医院第一医学中心核医学科 北京 100853
- 2. 中山大学肿瘤防治中心核医学科 广州 510060
- 折叠
摘要
Abstract
Objective:To investigate the effect of different acquisition duration of brain image of 18F-florbetaben(18F-FBB)positron emission tomography(PET)on standardized uptake value(SUV).Methods:Eight subjects who underwent 18F-FBB PET examination in Chinese PLA General Hospital from May 2021 to June 2021 were selected,including 5 persons of healthy control and 3 patients with mild cognitive impairment(MCI).All subjects underwent 18F-FBB PET imaging,and the dynamic PET images of them on brains were continuously acquired for 20 min between 90 and 110 min after the 18F-FBB injection was injected as(3.7-5.5 MBq/kg).Under the situation that other reconstruction parameters did not change,the images were reconstructed at 0-1,0-3,0-5,0-10,0-15 and 0-20 min,respectively.The same of region of interest(ROI)ranges were delineated in bilateral frontal cortex,bilateral temporal cortex,bilateral parietal cortex,posterior cingulate gyrus and cerebellar cortex of each group of images.And then,the corresponding mean standardized uptake value(SUVmean)of each region was obtained.The differences of SUVmean values of different ROI values between each group of data images and the images of 0-20 min were compared and analyzed.Results:There were significant differences in SUVmean between the acquired images in 0-1,0-3,0-5 and 0-10 min and the acquired standard images of 0-20 min(t=-7.569--2.410,P<0.05),respectively.There were no significant differences in SUVmean between the acquired images of 0-15 min and the acquired standard images of 0-20 min in the bilateral frontal lobe,bilateral temporal lobe,bilateral parietal cortex and posterior cingulate gyrus(P>0.05),only there was significant difference in the cerebellar cortex area between them(t=-5.597,P<0.001).Conclusion:The results of 15 min can reach to the similar results of 20 min in acquiring images,which can shorten the time of examination,and enhance the degrees of comfort and cooperation of patients in examination.It has clinical application value.关键词
阿尔茨海默病/正电子发射断层扫描/列表模式采集/最佳采集时长Key words
Alzheimer's disease/Positron emission tomography(PET)/Acquisition of list mode/Best acquisition duration分类
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吴世娜,刘猛,孙树伟,常燕,刘家金,王瑞民,徐白萱,姚树林..18F-FBB PET脑部图像采集中不同时长对感兴趣区域定量参数的影响研究[J].中国医学装备,2024,21(2):12-15,4.
