中国中医药信息杂志2024，Vol.31Issue(3)：13-18,6.DOI:10.19879/j.cnki.1005-5304.202302054
从肠道菌群-胆汁酸轴探讨高血压"土虚木郁"病机的生物学内涵
Exploration on the Biological Implications of"Earth Deficiency and Wood Depression"Pathogenesis of Hypertension from Intestinal Flora-bile Acid Axis
摘要
Abstract
There is a bidirectional relationship between intestinal flora and bile acids,and the imbalance of intestinal flora-bile acid axis metabolism is closely related to hypertension.Based on classical TCM literature and clinical practice,this article found that"earth deficiency"is the important pathological basis of hypertension,"wood depression"is the initiating factor of hypertension,and"earth deficiency and wood depression"is the key pathogenesis of hypertension.Combined with the research results of modern medicine and molecular biology,it is considered that the imbalance of intestinal flora and abnormal bile acid metabolism are closely related to the"earth deficiency"and"wood depression"of TCM respectively,and the imbalance of intestinal flora-bile acid axis coincides with the"earth deficiency and wood depression"of TCM in the process of hypertension.It is of great theoretical and practical significance to explore the biological connotation of hypertension"earth deficiency and wood depression"from the perspective of intestinal flora-bile acid axis for guiding TCM to prevent and treat hypertension.关键词
肠道菌群-胆汁酸轴/土虚木郁/高血压Key words
intestinal flora-bile acid axis/earth deficiency and wood depression/hypertension分类
医药卫生引用本文复制引用
司美龙,金华,刘敏科,王宇,张秋菊,刘双芳,凌必时,祁尚文..从肠道菌群-胆汁酸轴探讨高血压"土虚木郁"病机的生物学内涵[J].中国中医药信息杂志,2024,31(3):13-18,6.基金项目
国家自然科学基金(82160886) （82160886）
甘肃省自然科学基金(20JR10RA315) （20JR10RA315）
甘肃省中医药管理局科研项目(GZK-2019-24) （GZK-2019-24）
甘肃中医药大学中医学一级学科"岐黄英才"导师专项基金(2022-3) （2022-3）
