首页|期刊导航|中华医学杂志（英文版）|Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

Fangming Liu Liang Zheng Xiaochen Gai Hongbing Zhang Yuting Wu Baohui Zhang Shuhui Yang Kezhuo Shang Jie Li Pengju Zhang Weiwei Deng Linlin Chen

中华医学杂志（英文版）2024，Vol.137Issue(2)：181-189,9.

中华医学杂志（英文版）2024，Vol.137Issue(2)：181-189,9.DOI:10.1097/CM9.0000000000002816

Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

Fangming Liu ¹Liang Zheng ²Xiaochen Gai ³Hongbing Zhang ³Yuting Wu ⁴Baohui Zhang ⁵Shuhui Yang ³Kezhuo Shang ³Jie Li ³Pengju Zhang ³Weiwei Deng ³Linlin Chen⁶

作者信息

1. Department of Physiology,State Key Laboratory of Common Mechanism Research for Major Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Basic Medical Sciences and School of Basic Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China||Department of Physiology,Institute of Basic Medical Sciences and School of Basic Medicine,Graduate School of Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100005,China
2. Key Laboratory of Pediatric Hematology and Oncology,Ministry of Health,Institute of Pediatric Translational Medicine,Shanghai Children's Medical Center,Shanghai Jiao Tong School of Medicine,Shanghai 200127,China
3. Department of Physiology,State Key Laboratory of Common Mechanism Research for Major Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Basic Medical Sciences and School of Basic Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China
4. Department of Physiology,Institute of Basic Medical Sciences and School of Basic Medicine,Graduate School of Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100005,China
5. Department of Physiology,School of Life Science,China Medical University,Shenyang,Liaoning 110122,China
6. School of Life Sciences,Westlake University,Hangzhou,Zhejiang 310024,China
折叠

摘要

关键词

Liver cancer/p-catenin/Methotrexate/Nucleotide synthesis/Chemotherapy

Key words

Liver cancer/p-catenin/Methotrexate/Nucleotide synthesis/Chemotherapy

引用本文复制引用

Fangming Liu,Liang Zheng,Xiaochen Gai,Hongbing Zhang,Yuting Wu,Baohui Zhang,Shuhui Yang,Kezhuo Shang,Jie Li,Pengju Zhang,Weiwei Deng,Linlin Chen..Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis[J].中华医学杂志（英文版）,2024,137(2):181-189,9.

基金项目

This work was supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-1-I2M-018),the Haihe Laboratory of Cell Ecosystem Innovation Fund(No.22HHXBSS00012),and the National Natural Science Foundation of China(Nos.81730078 and 81872287). （No.2021-1-I2M-018）

中华医学杂志（英文版）

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ISSN：0366-6999

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