中药材2023，Vol.46Issue(8)：1976-1985,10.DOI:10.13863/j.issn1001-4454.2023.08.022
甘草中无机元素的测定及健康风险评估研究
Determination of Inorganic Elements in Glycyrrhizae Radix et Rhizoma and Health Risk Assessment
摘要
Abstract
Objective:To determine the contents of 28 inorganic elements in Glycyrrhizae Radix et Rhizoma,to find out the correla-tion between different elements and differences of sample from different producing areas,and to assess the health risk of heavy metals and harmful elements.Methods:The samples were treated by microwave digestion,and the contents of 28 inorganic elements in Glycyr-rhizae Radix et Rhizoma were determined by ICP-MS and atomic fluorescence spectrometry.The superimposed map of inorganic ele-ments was established.The differences of inorganic elements among Glycyrrhizae Radix et Rhizoma from different producing areas and the correlation between inorganic elements were analyzed by principal component analysis(PCA),orthogonal partial least squares dis-criminant analysis(OPLS-DA)and other chemometrics methods.The maximum tolerability of heavy metal elements per day(EDI),tar-get hazard coefficient(THQ)and carcinogenic risk(CR)were calculated for health risk assessment.Results:There was a certain corre-lation among different elements in Glycyrrhizae Radix et Rhizoma,and the contents of inorganic elements in Glycyrrhizae Radix et Rhi-zoma from different producing areas were significantly different.The results of EDI,THQ and CR showed that heavy metals and harmful elements in 30 batches of Glycyrrhizae Radix et Rhizoma had no obvious health risk to the exposed population.Conclusion:Inorganic el-ements can be used as an important basis for the differentiation of Glycyrrhizae Radix et Rhizoma from different producing areas.The contents of inorganic elements in Glycyrrhizae Radix et Rhizoma show certain regularity and correlation.The established method can provide reference for the establishment of quality evaluation system and clinical safety of Glycyrrhizae Radix et Rhizoma.关键词
甘草/无机元素/指纹图谱/产地分析/相关性分析/健康风险评估Key words
Glycyrrhizae Radix et Rhizoma/Inorganic elements/Fingerprints/Origin analysis/Correlation analysis/Health risks assessment分类
医药卫生引用本文复制引用
周德来,王行智,张菁菁,赵鲲鹏,冯金梁,李运,杨扶德..甘草中无机元素的测定及健康风险评估研究[J].中药材,2023,46(8):1976-1985,10.基金项目
2021年度甘肃高等学校产业支撑计划项目(2021CYZC-40) （2021CYZC-40）
甘肃省科技小巨人企业培育计划项目(17CXIJA084) （17CXIJA084）
2018年度甘肃省委组织部人才发展专项资金项目(甘组[2018]23号) （甘组[2018]23号）
2018年兰州市人才创新创业科技计划项目(2017-RC-112) （2017-RC-112）
