东华大学学报（英文版）2024，Vol.41Issue(1)：57-71,15.DOI:10.19884/j.1672-5220.202304002
可见光催化烯烃的三组分串联三氟甲基化/偕二氟烯丙基化
Visible-Light Photoredox-Catalyzed Three-Component Tandem Trifluoromethylation/Gem-Difluoroallylation of Alkenes
摘要
Abstract
An efficient,redox-neutral and visible-light-induced three-component tandem trifluoromethylation/gem-difluoroallylation reaction of electron-rich alkenes is described.Trifluoromethyl(—CF3)radical is generated from commercially available sodium trifluorome-thanesulfinate(CF3SO2Na),which is matched with the electron-rich alkene and α-trifluoromethyl alkene in turn,and finally,the polyfluoroolefin is obtained by β-F elimination.The advantages of this method are mild reaction conditions,excellent functional-group tolerance,broad substrate scope,and high reaction efficiency,which provides an opportunity for the late-stage modification of pharmaceuticals and natural product derivatives.关键词
自由基加成/三氟甲基化/偕二氟烯丙基化/烯烃Key words
radical addition/trifluoromethylation/gem-difluoroallylation/alkene分类
化学化工引用本文复制引用
袁汶雯,黄焰根,孟卫东..可见光催化烯烃的三组分串联三氟甲基化/偕二氟烯丙基化[J].东华大学学报（英文版）,2024,41(1):57-71,15.基金项目
National Natural Science Foundation of China(No.2199121) （No.2199121）
