吉林医药学院学报2024，Vol.45Issue(2)：85-89,5.
基于网络药理学与分子对接的欧前胡素治疗宫颈癌的作用机制
Network Pharmacology and Molecular Docking-Based Mechanisms of Action of Imperatorin in Treating Cervical Cancer
摘要
Abstract
Objective To explore the active ingredients and mechanism of action of imperatorin in the treatment of cervical cancer.Method By using network pharmacology to screen the medicinal components and cervical cancer targets of imperatorin and conducting relevant molecular docking technology validation.The pharmacological platform of the Chinese herbal medicine system searches for ef-fective ingredients and targets of imperatorin and uses OMIM and GeneCards databases to cross-screen target genes related to cervical cancer.Cytoscape software analyzes the common targets of cervical cancer and imperatorin,String database analysis and constructs PPI network analysis,Rstudo 4.0 software analysis and mapping,DAVID biological information database statistics,GO enrichment and KEGG enrichment analysis.Molecular docking using AutoDock analysis.Result The PPI network results showed that TERT,ESR1,PTGS2,PGR,PPARG,CA9,ESR2,AR,CASP9,ALPL,and CLK1 may be core targets for imperatorin and cervical cancer.GO enrichment re-sulted in 26 biological processes,while KEGG enrichment resulted in 6 main pathways,including Chemical cancer receptor activation,Estrogen,Break cancer,VEGF,Prolactin,and other signaling pathways.The molecular docking results show that compounds such as LYS-243,ARG-240,and GLU-272 have good binding power with the core targets of cervical cancer.Conclusion Imperatorin may play an anti-therapeutic role against cervical cancer by binding to ESR1,PGR,PTGS2,ESR2,CASP9,and other signaling pathways such as VEGE,estrogen,and progesterone.关键词
欧前胡素/宫颈癌/网络药理学/作用机制Key words
imperatorin/cervical cancer/network pharmacology/mechanism of action分类
医药卫生引用本文复制引用
马畅,侯婷予,王雪莹,刘琰..基于网络药理学与分子对接的欧前胡素治疗宫颈癌的作用机制[J].吉林医药学院学报,2024,45(2):85-89,5.基金项目
国家自然科学基金青年基金(82302563) （82302563）
