国际口腔医学杂志2024，Vol.51Issue(2)：193-200,8.DOI:10.7518/gjkq.2024005
免疫球蛋白G4相关性唾液腺炎临床特点及诊疗进展
Diagnosis and treatment progress and clinical characteristics of immunoglobulin G4-related sialadenitis
摘要
Abstract
Immunoglobulin G4-related sialadenitis(IgG4-RS)is a chronic autoimmune disease closely associated with IgG4.This disease is an uncommon disorder in the clinical setting,and its etiology is unknown.The major clinical fea-tures of IgG4-RS is a painless,persistent enlargement of the salivary gland,especially the submandibular gland.Periphe-ral blood examination show that IgG4 levels are elevated in the serum of most patients,and their lymphoplasmic cells are infiltrated.In the advanced stage of the disease,tissue lesions can present in various organs of the body.Histopathology is the most reliable diagnostic method.Glucocorticoids are recommended as the primary clinical treatment.Biologics can al-so be used as targeted therapy at this stage.Based on domestic and international literature,we review herein the etiology,clinical manifestations,diagnosis and differential diagnosis,and treatment and prognosis of IgG4-RS to aid the diagnosis,treatment,and subsequent research of the disease.关键词
免疫球蛋白G4/唾液腺炎/免疫反应/诊断/治疗Key words
immunoglobulin G4/sialadenitis/immunoreaction/diagnosis/treatment分类
医药卫生引用本文复制引用
张宇,贾志宇,唐慧芳,张志勇,李文静,田松波..免疫球蛋白G4相关性唾液腺炎临床特点及诊疗进展[J].国际口腔医学杂志,2024,51(2):193-200,8.基金项目
河北省自然科学基金(H2019206129) Hebei Provincial Natural Science Foundation(H2019206129) （H2019206129）
