国际口腔医学杂志2024，Vol.51Issue(2)：201-207,7.DOI:10.7518/gjkq.2024031
机械应力下初级纤毛在骨和颞下颌关节软骨改建中力学感知作用的研究进展
Research progress of primary cilia in bone remodelling and reconstruction of temporomandibular joint cartilage under mechanical stress
摘要
Abstract
Tooth movement and temporomandibular joint remodelling during orthodontic treatment are typical biome-chanical processes that involve bone remodelling and maintenance of cartilage homeostasis.Primary cilia are mechanore-ceptors that widely exist on the surface of mesenchymal stem cells(MSCs),osteoblasts,osteocytes,chondrocytes,and other cells.Under mechanical stress,primary cilia could promote the osteogenic differentiation of MSCs and maintain the mechani-cal sensitivity of osteoblasts.Primary cilia could also promote the deposition of the bone matrix,upregulate the functional activity of osteocytes,and indirectly regulate the activity of osteoclasts.They promote the proliferation,differentiation,and endochondral ossification of chondrocytes by transducing multiple signalling pathways and thus play an important role in bone-cartilage tissue remodelling.This article aims to review the research progress of primary cilia in alveolar bone remodelling and reconstruction of temporomandibular joint cartilage.Relevant molecular mechanisms are discussed.This work pro-vides a reference to further explore the mechanisms of bone and cartilage tissue remodelling during orthodontic treatment.关键词
初级纤毛/机械转导/正畸牙齿移动/颞下颌关节Key words
primary cilia/mechanotransduction/orthodontic tooth movement/temporomandibular joint分类
医药卫生引用本文复制引用
薛晴,齐慧川,胡敏..机械应力下初级纤毛在骨和颞下颌关节软骨改建中力学感知作用的研究进展[J].国际口腔医学杂志,2024,51(2):201-207,7.基金项目
国家自然科学基金青年科学基金(82100956) National Natural Science Foundation of China Youth Science Foundation Project(82100956) （82100956）
