国际口腔医学杂志2024，Vol.51Issue(2)：208-216,9.DOI:10.7518/gjkq.2024027
晚期糖基化终产物在口腔鳞状细胞癌发展及治疗的研究进展
Role of advanced glycosylation end-products and their receptors in the progression and treatment of oral squamous cell carcinoma
摘要
Abstract
The molecular mechanisms underlying the occurrence and progression of oral squamous cell carcinoma(OS-CC)are still not fully understood.This topic remains a focal point of research to comprehend the malignant biological characteristics of OSCC and explore targeted therapeutic approaches.Advanced glycation end-products(AGEs)and their receptors(RAGE)interact with other receptors in vivo,thereby activating multiple signaling pathways to induce the syn-thesis of interleukins,growth factors,and cytokine synthesis.Recent studies have shown that the activation of AGE/RAGE-related signaling pathways affects the proliferation,invasion,angiogenesis,and local recurrence of oral cancer and is associated with poor prognosis in patients with advanced oral cancer.This paper reviews the relationship between AG-Es/RAGE and OSCC with the aim of providing potential targets for OSCC treatment.关键词
口腔鳞状细胞癌/晚期糖基化终产物/晚期糖基化终末产物受体Key words
oral squamous cell carcinoma/advanced glycation end-product/receptor of advanced glycation end-product分类
医药卫生引用本文复制引用
王文轩,刘云坤,李冰芷,黄能文,侯泽宇,唐金茹,李龙江..晚期糖基化终产物在口腔鳞状细胞癌发展及治疗的研究进展[J].国际口腔医学杂志,2024,51(2):208-216,9.基金项目
国家自然科学基金(82141130) National Natural Science Foundation of China(82141130) （82141130）
