临床与病理杂志2023，Vol.43Issue(12)：2158-2163,6.DOI:10.11817/j.issn.2095-6959.2023.230085
SPIN1与恶性肿瘤
SPIN1 and malignant tumors
摘要
Abstract
SPIN1(spindlin 1)is a histone-modified reader protein that promotes the expression of ribosome RNA by recognizing trimethylation of lysine 4 on histone H3 protein subunit(H3K4me3),thereby influencing epigenetic regulation and exerting its biological function.SPIN1 is overexpressed in various malignant tumors and can be negatively regulated by various long non-coding RNAs(lncRNAs),microRNAs(miRNAs),and circular RNAs(circRNAs).It can also be transcriptionally activated by the transcription factor adenovirus E2 factor 1(E2F1)and promote tumorigenesis and development through signaling pathways associated with tumorigenesis such as Wnt,phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),rearrangement during transfection(RET)factor,murine double minute 2-p53(MDM2-p53),closely related to poor prognosis.With the deepening research on SPIN1,it has been found that SPIN1 may serve as a potential target for the treatment of various malignant tumors.Inhibitors targeting the interaction between SPIN1 and H3K4me3 have been developed to block the carcinogenic capacity of SPIN1.关键词
SPIN1/组蛋白阅读器/恶性肿瘤/小分子抑制剂Key words
spindlin 1/histone reader/malignant tumor/small molecule inhibitors引用本文复制引用
肖瑶,吕蓓蓓..SPIN1与恶性肿瘤[J].临床与病理杂志,2023,43(12):2158-2163,6.基金项目
国家自然科学基金(82103490) （82103490）
山东省自然科学基金(ZR2021MH382).This work was supported by the National Natural Science Foundation(82103490)and the Natural Science Foundation of Shandong Province(ZR2021MH382),China. （ZR2021MH382）
