摘要
Abstract
Hepatocellular Carcinoma(HCC)has a high incidence and mortality rate.In China,most patients are often infected with hepatitis B virus and have liver cirrhosis,and are already in the middle to late stages at the time of diagnosis,resulting in poor prognosis.MicroRNA(miRNA)can regulate the expression of tumor-related genes at the post-transcriptional level,thereby playing a crucial role in the occurrence and development of tumors.MiR-214 is a core regulatory factor in HCC and is significantly down-regulated in HCC.MiR-214 can affect the occurrence and development of HCC by regulating iron death,proliferation,apoptosis,invasion,hypoxia,competitive endogenous RNA networks,and liver fibrosis in HCC cells.Additionally,in HCC treatments,miR-214 has a regulatory effect on the sensitivity and resistance of HCC to chemotherapy and immunotherapy.Therefore,an in-depth exploration of the expression regulation mechanism and biological function of miR-214 in HCC can provide guidance and a basis for the study of clinical screening markers and therapeutic targets for HCC.关键词
microRNA-214/微RNA/肝细胞癌/生物标志物Key words
microRNA-214/microRNA/hepatocellular carcinoma/biomarkers
