摘要
Abstract
The main pathological changes in diabetic retinopathy are retinal microvascular lesions and retinal neurodegeneration,with neurodegeneration occurring before microvascular lesions.The pathogenesis of diabetic retinal neurodegeneration(DRN)involves inflammation,oxidative stress,glutamate accumulation,autophagy,downregulation of neurotrophic factors,and apoptosis.At present,the treatment for DRN is not well established.In recent years,targeted drugs for DRN including aldose reductase inhibitors,pregabalin,maolin,resveratrol,quercetin,lutein,niacinamide,guanidine,mammalian target of rapamycin activators,acetylase,brain-derived neurotrophic factor,β-nerve growth factor,somatostatin,Raf-1 kinase inhibitory protein,have been shown to delay or alleviate the progression of DRN to a certain extent.It is expected to provide new diagnostic and therapeutic strategies as well as prevention strategies for diabetic retinopathy in the future.关键词
糖尿病视网膜病变/糖尿病视网膜神经变性/靶向治疗Key words
diabetic retinopathy/diabetic retinal neurodegeneration/targeted therapy
