海洋科学2023，Vol.47Issue(12)：93-101,9.DOI:10.11759/hykx20221028001
螺旋藻藻蓝蛋白对酒精性肝损伤大鼠肠道菌群的影响
Effect of Spirulina phycocyanin on intestinal flora of rats with alcoholic liver injury
摘要
Abstract
Alcoholic liver disease(ALD)is one of the most common liver diseases in China and is a serious health risk to people's health.Currently,effective methods to treat ALD are lacking.Spirulina phycocyanin(PC)is a nat-urally occurring protein with anti-inflammatory and antioxidant properties.In this study,we investigated the pro-tective effect of PC on the intestinal flora of rats with alcoholic liver injury.Using an alcohol-induced alcoholic liver injury model,rats were randomly divided into four groups:control group,model group,positive control group,and PC group.After gavage of PC intervention,pathological analysis of the extent of liver injury was determined using Masson and hematoxylin and eosin staining of liver sections,followed by detection of the composition and structure of rat intestinal flora using 16S rRNA high-throughput sequencing technology.The intestinal flora of rats in the model group was disrupted,significantly reducing the abundance of Bifidobacteria,a species that reduces liver inflammation and liver enzymes;however,after oral administration of PC,the abundance of Bifidobacteria significantly increased.Furthermore,the abundance of Lactobacillus slightly increased following alcohol induction,thereby promoting alcohol metabolism.PC was able to alleviate alcohol-induced liver injury in rats by altering the composition of intestinal flora.关键词
酒精性肝损伤/藻蓝蛋白/肠道菌群Key words
alcoholic liver injury/phycocyanin/intestinal flora分类
医药卫生引用本文复制引用
王静,臧帆,秦松..螺旋藻藻蓝蛋白对酒精性肝损伤大鼠肠道菌群的影响[J].海洋科学,2023,47(12):93-101,9.基金项目
吉林省与中国科学院科技合作高技术产业化专项资金项目(2023SYHZ0040)[High tech industrialization special project in cooperation between Jilin Province and the Chinese Academy of Sciences,No.2023SYHZ0040] （2023SYHZ0040）
