吉首大学学报（自然科学版）2024，Vol.45Issue(1)：48-55,8.DOI:10.13438/j.cnki.jdzk.2024.01.009
温敏印迹柱对薯蓣皂素的选择保留和控制缓释
Selective Retention and Controlled Release Behavior of a Temperature-Sensitive Imprinted Polymer Monolith for Diosgenin
摘要
Abstract
A temperature-sensitive imprinted polymer was prepared with diosgenin as the template and with α-methacrylic acid(MAA)and N-Isopropylacrylamide(NIPAM)as mixed-functional monomer in present work.Then,this imprint polymer was filled into an empty stainless steel tube to produce a mo-lecularly imprinted polymer column and the retention and controlled release behavior for this column to-ward the template as a drug molecule were evaluated in chromatographic model.The influence of column temperature,effluent composition and pH,and effluent ion strength on the retention selectivity and con-trolled release behavior for this imprint column was investigated.Results indicated that column tempera-ture possessed significant influence on retention and controlled-release behavior for the imprint column.When it was set at 303 K(near critical temperature of this imprinted polymer),the column had the strongest retention capacity toward the template.Moreover,when column temperature was higher and/or lower than 303 K,a decreased retention capacity and an accelerated template release for the imprint col-umn was observed.In addition,effluent composition,pH and effluent ion strength also affect the reten-tion and controlled-release for this imprint column.At 303 K column temperature and with effluent of 0.001 mol/L(pH 7.4),the release time was as long as 1 050 min.关键词
分子印迹/温敏印迹柱/薯蓣皂素/保留行为/药物控制释放Key words
molecular imprint/temperature-sensitive imprinted polymer/diosgenin/retention behavior/controlled-release of drug分类
化学化工引用本文复制引用
刘美君,彭雨婷,肖真仪,周小辉,简宇轩,毛琳,李辉..温敏印迹柱对薯蓣皂素的选择保留和控制缓释[J].吉首大学学报（自然科学版）,2024,45(1):48-55,8.基金项目
国家自然科学基金资助项目(21865011) （21865011）
湖南省大学生省级创新课题(S202110531050) （S202110531050）
湘西自治州科技创新计划重点项目(2019SF2003) （2019SF2003）
吉首大学本科生创新课题(JDXB2022024) （JDXB2022024）
