健康研究2024，Vol.44Issue(1)：70-76,7.DOI:10.19890/j.cnki.issn1674-6449.2024.01.015
铅暴露对注意缺陷多动障碍影响的系统综述
Systematic review of the effects of lead exposure on attention deficit hyperactivity disorder
摘要
Abstract
Objective To investigate the impact of lead exposure on attention deficit hyperactivity disorder(ADHD),this study will conduct a systematic review of the correlation between lead exposure and ADHD,as well as the relationship between the level of lead exposure and the symptoms of ADHD.Methods The literature pertaining to the connection between lead exposure and ADHD during the period of 2016 to 2022 was gathered and compiled from the appropriate literature database.The quality of the literature was evaluated and the literature's features were extracted for the purpose of statistical analysis.Results A total of 1 884 pieces of literature were identified with 19 being included in the final analysis.The findings from 13 case-control studies revealed a significantly higher blood lead level among children with ADHD as compared to their healthy counterparts.The combined standardized mean difference and 95%confidence interval were 0.85(0.45-1.25),and the combined effect size test z-score was 4.14(P<0.001).Four studies demonstrated a heightened risk of ADHD due to lead exposure,whilst five studies indicated an association between lead exposure and at least one ADHD symptom.In contrast,one study found no correlation between lead exposure and ADHD symptoms.Conclusions Lead levels are associated with ADHD in children,and lead exposure is an independent risk factor for the development of ADHD in children.There is a significant correlation between lead exposure and the severity of ADHD symptoms.Therefore,it is essential to take appropriate intervention measures to reduce children's exposure to lead actively and prevent the occurrence of ADHD.关键词
铅/注意力缺陷多动障碍/症状/系统综述/Meta分析Key words
lead/attention deficit hyperactivity disorder/symptom/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
周新玉,郭岚敏,杜美玲,吕新悦..铅暴露对注意缺陷多动障碍影响的系统综述[J].健康研究,2024,44(1):70-76,7.基金项目
佳木斯大学优秀学科团队项目(JDXKTD-219006) （JDXKTD-219006）
