健康研究2024，Vol.44Issue(1)：90-94,5.DOI:10.19890/j.cnki.issn1674-6449.2024.01.019
抗M型磷脂酶A2受体抗体水平对原发性膜性肾病患者临床特征及预后的影响
Impact of anti-M-type phospholipase A2 receptor antibody levels on clinical features and prognosis of individuals with primary membranous nephropathy
摘要
Abstract
Objective To compare and analyse the clinical features,therapeutic effects,and prognosis of primary membranous nephropathy(PMN)with different levels of anti-phospholipase A2 receptor antibodies.Methods Retrospectively collecting data from 161 PMN patients,this study classified patients into three groups based on their anti-phospholipase A2 receptor antibody levels:44 high titer,57 low titer,and 60 negative.The study then compared the clinical features,therapeutic effects,and prognosis of each group.Factors contributing to total remission and poor prognosis were analyzed using Cox regression.Results The study found that the proportion of males,hematuria,24-hour urine protein volume,and D2 polymer level were significantly higher in the high-efficiency price group and low-efficiency price group compared to the negative group(all P<0.05).The study found that the proportion of patients with combined nephrotic syndrome was higher in the high-efficiency price group than in the negative group.Additionally,the levels of diastolic blood pressure,blood creatinine,cholesterol,and low-density lipoprotein were also higher in the high-efficiency price group.Conversely,the levels of blood albumin and IgG were lower in the high-efficiency price group than in the negative group.All of these differences were statistically significant(P<0.05).The rate of clinical remission was statistically significantly lower in the high potency group(70.5%)compared to the low potency group(87.7%)and the negative group(88.3%)(χ2=7.088,P=0.029).The Cox regression analysis revealed that anti-PLA2R antibody levels of>150 RU/mL were an independent factor influencing the attainment of clinical remission in PMN patients(HR=0.451,95%CI 0.288～0.706,P = 0.001).Additionally,unremitting nephropathy was identified as an independent factor influencing the occurrence of poor renal prognosis in PMN patients(HR = 17.922,95%CI 3.465～92.698,P = 0.001).Conclusions Patients diagnosed with membranous nephropathy and high levels of anti-PLA2R antibodies are more likely to experience severe illness at the onset of the disease and may have a poor response to treatment.关键词
原发性膜性肾病/抗M型磷脂酶A2受体抗体/治疗反应/预后Key words
primary membranous nephropathy/Anti-M-Type phospholipase A2 receptor antibody/therapeutic effect/prognosis分类
医药卫生引用本文复制引用
潘林林,包蓓艳..抗M型磷脂酶A2受体抗体水平对原发性膜性肾病患者临床特征及预后的影响[J].健康研究,2024,44(1):90-94,5.基金项目
宁波市医学科技计划项目(2021Y51) （2021Y51）
