摘要
Abstract
Objective The aim of this study was to investigate the impact of varying doses of oxytocin(OT)on the progression of labour,coagulation,and maternal and infant outcomes in pregnant women undergoing trial of labour after cesarean section(TOLAC)for a second pregnancy.Methods A retrospective analysis was conducted on clinical medical data from 138 pregnant women with TOLAC who were admitted to the hospital between January 2021 and December 2021.The pregnant women were divided into three groups based on the total amount of OT used during labor:low-dose group(61 cases),middle-dose group(45 cases),and high-dose group(32 cases).The study compared the progress of labor,coagulation function,labor mode,pregnancy outcomes,and perinatal outcomes among the three groups.Results There were no statistically significant differences in the duration of the first,second,third,and total stages of labour among the three groups(P>0.05).Compared to the pre-medication period,the three groups showed a statistically significant decrease in prothrombin time(PT)and activated partial thromboplastin time(APTT),as well as an increase in fibrinogen(FIB)levels after medication(P<0.05).However,there were no significant differences in PT,APTT,and FIB levels among the three groups after medication(P>0.05).The occurrence of placental abruption and neonatal hyperbilirubinaemia was lower in the small-dose and medium-dose groups compared to the high-dose group,and the difference was statistically significant(P<0.05).Conclusions Oxytocin(OT)can improve uterine contractility and coagulation function in pregnant women undergoing TOLAC.However,high doses of OT may increase the risk of placental abruption and neonatal hyperbilirubinemia.关键词
缩宫素/剖宫产术后再次妊娠/阴道试产/凝血功能/母婴结局Key words
oxytocin/re-pregnancy after cesarean section/vaginal trial labor/coagulation function/maternal-infant out-comes分类
医药卫生
