环境与职业医学2024，Vol.41Issue(2)：226-233,8.DOI:10.11836/JEOM23310
生命早期抗生素暴露与儿童健康的流行病学研究进展
Epidemiological research advances on antibiotic exposure in early life and child health
摘要
Abstract
Early life is a critical window period that determines the growth and development of chil-dren,but this delicate and complex period is highly susceptible to the disturbance of various ex-ogenous chemicals,which in consequence may lead to short-term or long-term adverse health effects in human beings.The massive use of antibiotics has contributed to widespread exposure in early life,along with the potentially adverse effects on child health,and has caused great concern in public health.This review summarized recent epidemiological studies on the population with early-life antibiotic exposure and associated health outcomes such as growth and development,allergies,and psycho-behavioral problems in children,as well as potential biological mechanisms underlying these associations.Current findings suggested that antibiotic exposure early in life,including pregnancy and infancy,is strongly associated with childhood allergic diseases(e.g.,atopic dermatitis and asthma),growth and development(e.g.,obesity and birth length),and childhood psycho-behavioral problems(e.g.,autism and anxiety).It also suggested that antibiotic exposure may affect individual health through gut microbiota,thyroid function,inflammation factors,mitochondrial function,and epigenetic mechanisms.In the future,more large prospective birth cohorts should be established to determine the levels of internal exposure to different types of antibiotics at multiple time points in early life and to explore their associations with child health outcomes,as well as to further validate relevant mechanisms,aiming to provide high-quality scientific evidence for research on child health associated with environmental expo-sure in early life.关键词
抗生素/环境暴露/生命早期/儿童疾病/肠道微生物群Key words
antibiotic/environmental exposure/early life/childhood disease/gut microbiota分类
医药卫生引用本文复制引用
熊万红,耿梦龙,陶芳标..生命早期抗生素暴露与儿童健康的流行病学研究进展[J].环境与职业医学,2024,41(2):226-233,8.基金项目
国家自然科学基金项目(82204053) （82204053）
安徽省教育厅高校自然科学研究项目重点项目(KJ2021A0222) This study was funded. （KJ2021A0222）
