临床输血与检验2024，Vol.26Issue(1)：92-100,9.DOI:10.3969/j.issn.1671-2587.2024.01.015
Kidd血型相关SLC14A1基因在肾透明细胞癌中的表达及临床意义
Expression of Kidd Blood Group Related SLC14A1 Gene in Kidney Renal Clear Cell Carcinoma and Its Clinical Significance
周仁龙 1钟靖 2唐丹丹3
作者信息
- 1. 深圳市龙华区中心医院输血科 518100
- 2. 邵阳市中心医院输血科 422000
- 3. 深圳市南山区医疗集团总部 518000
- 折叠
摘要
Abstract
Objective To investigate the expression and clinical significance of Kidd blood group solute carrier family 14(SLC14A1)gene in kidney clear cell carcinoma(KIRC).Methods Bioinformatics analysis was used to analyze and evaluate the expression and clinical prognostic value of SLC14A1 in KIRC in combination with SANGERBOX,GEPIA,UALCAN,STRING and other databases.Results Kidd blood group SLC14A1 gene was significantly up-regulated in 4 tumors(P＜0.05),and significantly down regulated in 22 tumors(P＜0.05).The mRNA expression level of SLC14A1 in KIRC tissues was significantly lower than that in normal tissues(tumor1.35±1.69 vs normal 3.90±2.47,P＜0.05).Survival analysis showed that the expression level of SLC14A1 was significantly positively correlated with the overall survival rate of KIRC(P＜0.05).Based on univariate Cox and multivariate Cox regression analysis,low expression of SLC14A1 was a prognostic risk factor for KIRC.KEGG enrichment analysis dominates in metabolic pathways.GO enrichment analysis dominates in phagosome acidification,trivalent iron transport and transferrin transport.Conclusion The low expression of Kidd blood group SLC14A1 gene in KIRC is associated with the occurrence,development and poor prognosis of KIRC,which is expected to be used as a possible target for KIRC diagnosis,prognosis judgment and treatment.关键词
肾透明细胞癌/Kidd血型/SLC14A1基因/生物信息学/癌症基因组图谱Key words
Kidney renal clear cell carcinoma/Kidd blood group/SLC14A1 gene/Bioinformatics/TCGA分类
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周仁龙,钟靖,唐丹丹..Kidd血型相关SLC14A1基因在肾透明细胞癌中的表达及临床意义[J].临床输血与检验,2024,26(1):92-100,9.
