南京医科大学学报（自然科学版）2024，Vol.44Issue(3)：329-335,7.DOI:10.7655/NYDXBNSN230742
基于可降解两性离子聚碳酸酯纳米胶束的设计合成及其血液长循环研究
Study on long blood-circulation of nano-micelles based on biodegradable zwitterionic polycarbonate
摘要
Abstract
Objective:To overcome the drawbacks of traditional nanomedicines with a poor stability,a short blood circulation,and a high immunogenicity,a novel zwitterionic nano-vector with sterling stability and non-specific protein resistance were designed and prepared.Methods:A biodegradable carboxybetaine(CB)-modified polycarbonate[PAC(TCB)]was designed and synthesized by ring-opening polymerization and Michael addition reaction,which can form the micelles of around 160 nm via a solvent displacement method.Results:Cellular uptake and cytotoxicity experiments demonstrated that PAC(TCB)micelles possessed the superior characteristics of an efficient cell internalization,and an excellent biocompatibility.The hemolysis assay and in vivo pharmacokinetic experiments confirmed that PAC(TCB)micelles led to a low immunogenicity,a prolonged blood circulation and a negligible antibody effect after repeated injections.Conclusion:The biodegradable zwitterionic-functionalized polycarbonate displays a colossal potential as the nano-vector in drug delivery.关键词
两性离子聚碳酸酯/低免疫原性/抗蛋白吸附/长循环/药物递送Key words
zwitterionic polycarbonate/low immunogenicity/protein-adsorption resistance/long blood circulation/drug delivery分类
医药卫生引用本文复制引用
张平,徐云燕,陈莹,王可,陈维,张庆明..基于可降解两性离子聚碳酸酯纳米胶束的设计合成及其血液长循环研究[J].南京医科大学学报（自然科学版）,2024,44(3):329-335,7.基金项目
国家自然科学基金(52173294) （52173294）
