南京医科大学学报（自然科学版）2024，Vol.44Issue(3)：336-341,351,7.DOI:10.7655/NYDXBNSN230836
迷迭香酸-锌配合物的抗氧化和抗菌性研究
Study on antioxidant and antimicrobial properties of rosmarinic acid-zinc complexes
摘要
Abstract
Objective:To investigate the structure,antioxidant,antimicrobial and biocompatibility of rosmarinic acid(RA)and zinc(Zn)complexes.Methods:The structures of zinc complexes with rosmarinic acid(RA-Zn)were analyzed by scanning electron microscopy,infrared and ultraviolet-visible spectroscopy.The effects of RA and RA-Zn on the proliferative activity of osteoblasts were compared by cell proliferation assay.The antioxidant properties were analyzed by ferric ion reducing antioxidant power assay and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)ammonium salt(ABTS)free radical scavenging assay.The inhibitory activities of RA and RA-Zn against Straphylococcus aureus were compared by the minimum inhibitory concentration assay.Results:The complex(RA-Zn)was successfully synthesized.On the 5th day of treatment,the effect of RA-Zn on promoting osteoblast proliferation was superior to that of RA(P＜0.05).RA-Zn of 200 μmol/L had stronger antioxidant capacity than RA(P＜0.05).RA inhibited Staphylococcus aureus activity at the concentration of ≥400 μmol/L(P＜0.05),while RA-Zn showed these inhibitory effect at the concentration of ≥ 25 µmol/L(P＜0.05).Conclusion:The antioxidant and antimicrobial properties are enhanced by the complexation of RA and Zn ions,which promotes osteoclast proliferation.关键词
迷迭香酸-锌配合物/抗氧化/抗菌Key words
rosmarinic acid-zinc complexes/antioxidant/antibacterial分类
医药卫生引用本文复制引用
蒋骋昊,卞晶晶,谢海峰..迷迭香酸-锌配合物的抗氧化和抗菌性研究[J].南京医科大学学报（自然科学版）,2024,44(3):336-341,351,7.基金项目
江苏省重点研发计划(社会发展)项目(BE2022787) （社会发展）
江苏省大学生创新训练重点项目(202210312004Z) （202210312004Z）
