临床神经病学杂志2024，Vol.37Issue(1)：15-19,5.
静脉滴注联合鞘内/脑室内注射多粘菌素治疗颅内多重耐药菌感染有效性和安全性的Meta分析
Meta-analysis of efficacy and safety of intravenous combined with intrathecal/intraventricular injection of polymyxin against intracranial infection with multidrug-resistant bacteria
周益毅 1龙勇 1谢尊椿 1王联群 1洪道俊1
作者信息
- 1. 330006 南昌大学江西医学院第一附属医院神经内科
- 折叠
摘要
Abstract
Objective Evaluation of the efficacy and safety of intravenous(IV)combined with intrathecal/intraventricular injection(ITH/IVT)of polymyxin against intracranial infection with multidrug-resistant bacteria.Methods The databases,including Wanfang,VIP,Chinese Biomedical Literature,Pubmed,Embase,ScienceDirect,and Cochrane Library were searched,case-control studies on IV+ITH/IVT polymyxin against intracranial infection with multidrug-resistant bacteria by January 2023 were screen.RevMan 5.4 software was used for meta-analysis.Results A total of 9 retrospective studies were included.The fatality rate in IV+ITH/IVT polymyxin group was significantly lower than that in IV group(OR =0.19,95%CI:0.11-0.35,P＜0.01).There was no significant difference in ICU hospitalization days(OR =-2.32,95%CI:-23.59-18.89,P =0.83)and adverse reaction rate(OR =0.93,95%CI:0.26-3.38,P =0.91)between IV+ITH/IVT group and IV group.Conclusion IV+ITH/IVT polymyxin in treating the intracranial infection with multidrug-resistant bacteria can significantly reduce fatality rate,and does not significantly increase adverse reactions.关键词
多粘菌素/颅内感染/鞘内注射/脑室内注射/Meta分析Key words
polymyxin/encephalitis/intrathecal injection/intraventricular injection/Meta analysis分类
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周益毅,龙勇,谢尊椿,王联群,洪道俊..静脉滴注联合鞘内/脑室内注射多粘菌素治疗颅内多重耐药菌感染有效性和安全性的Meta分析[J].临床神经病学杂志,2024,37(1):15-19,5.
