临床神经病学杂志2024，Vol.37Issue(1)：37-40,4.
抗神经束蛋白186抗体阳性的郎飞结区/结旁疾病的临床特点(附1例报告)
Clinical manifestations of nodo-paranodopathy with anti-neurofascin 186 antibody positive(report of one case)
董思语 1孙美 2陈聪 2王静 3金庆文 4程虹2
作者信息
- 1. 241001 皖南医学院第一附属医院弋矶山医院神经内科
- 2. 南京医科大学第一附属医院神经内科
- 3. 南京医科大学第一附属医院肾内科
- 4. 南京医科大学附属逸夫医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the clinical manifestations of nodo-paranodopathy(NPP)with anti-neurofascin 186(NF186)antibody positive.Methods The clinical data of a NPP patient with cranial nerve damage caused by anti-NF186 antibody positive was retrospectively analyzed.Results The patient was a 70-year-old male with sudden speech disorder and dysphagia one month ago.Glucocorticoid therapy was discontinued after improvement.The patient's speech,swallowing,chewing,bristling,turning and head-up movements were laborious and progressively aggravated 5 days ago.The EMG examination of the limbs was normal,and the serum and CSF anti-NF186 antibody were positive.The curative effect of glucocorticoid treatment was not obvious,and the symptoms were significantly improved after plasma exchange treatment.Conclusions Anti-NF186 antibody-positive NPP has late onset age,severe illness and accompanied with cranial nerves damage.Conventional hormone therapy is not effective,but plasma exchange therapy is effective.关键词
抗神经束蛋白抗体/颅神经损害/郎飞结/血浆交换Key words
anti-neurofascin 186 antibody/cranial nerves injuries/Ranvier node/plasma exchange分类
医药卫生引用本文复制引用
董思语,孙美,陈聪,王静,金庆文,程虹..抗神经束蛋白186抗体阳性的郎飞结区/结旁疾病的临床特点(附1例报告)[J].临床神经病学杂志,2024,37(1):37-40,4.
